Age-related differences in the mechanism of nondipping among patients with obstructive sleep apnea syndrome

Clinical and Experimental Hypertension : CHE
Nobuo SasakiYasuki Kihara

Abstract

The frequency of nondipper (those lacking the normal drop in nocturnal blood pressure [BP]) is high in patients with obstructive sleep apnea syndrome (OSAS). The objective of this study is to investigate age-related differences in the nocturnal BP profile of patients with OSAS. The study subjects included 214 patients with polysomnography-diagnosed OSAS. The status of dipper or nondipper was determined by 24-hour ambulatory BP measurements. We divided the subjects into three groups by age (younger, middle-aged, and elderly) and compared the frequency and sleep profiles of nondippers in the different age groups. The prevalence of nondippers was significantly higher in the elderly OSAS group than in the younger and middle-aged OSAS groups (69% vs. 45%, 47%; P < .05). In the younger OSAS group, nondippers, when compared with dippers, were characterized by higher apnea-hypopnea index (AHI, 48.2 ± 27.1 vs. 37.4 ± 23.0 times/h, P < .05), whereas in the middle-aged and elderly OSAS groups, the AHI of nondippers was almost identical to that of dippers. On the other hand, in the elderly OSAS group, nondippers, when compared with dippers, had shorter periods of slow wave sleep as measured by nonrapid eye movement stage 3-4, whereas nondi...Continue Reading

References

Dec 1, 1991·Sleep·S Ancoli-IsraelO Kaplan
Oct 1, 1995·The Journal of Clinical Investigation·V K SomersF M Abboud
Feb 4, 1993·The New England Journal of Medicine·V K SomersF M Abboud
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·E O BixlerA Kales
Jul 31, 1998·Psychiatry and Clinical Neurosciences·A NodaM Yokota
Jun 1, 1995·Journal of Sleep Research·W PankowF W Lohmann
Apr 19, 2000·JAMA : the Journal of the American Medical Association·F J NietoT G Pickering
May 11, 2000·The New England Journal of Medicine·P E PeppardJ Skatrud
Aug 10, 2001·Current Opinion in Nephrology and Hypertension·T G Pickering, K Kario
Oct 6, 2001·American Journal of Hypertension·J S LoredoJ E Dimsdale
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·R S Leung, T D Bradley
Nov 10, 2004·Sleep·José S LoredoJoel E Dimsdale
Jan 26, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Osamu ShirasakiKazuomi Kario
Jan 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Esra TasaliEve Van Cauter
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kohei NagataKenjiro Kimura
May 13, 2009·Archives of Internal Medicine·Elizabeth Silaid MuxfeldtGil Fernando Salles
May 23, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuomi Kario
Nov 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Friedhelm SaykChristoph Dodt

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Citations

Jun 22, 2013·Clinical and Experimental Hypertension : CHE·Murat SunbulAltug Cincin
Mar 28, 2013·Clinical and Experimental Hypertension : CHE·Nobuo SasakiYasuki Kihara
Sep 24, 2015·Clinical and Experimental Hypertension : CHE·Nobuo SasakiYasuki Kihara
Nov 21, 2013·The Journal of Pediatrics·Tamara S HannonSilva A Arslanian
Dec 13, 2016·Clinical and Experimental Hypertension : CHE·Nobuo SasakiYasuki Kihara
Jan 13, 2018·Internal Medicine·Hiromitsu SekizukaYoshihiro J Akashi
Feb 20, 2019·Hypertension·Meghna P MansukhaniVirend K Somers
Jul 19, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Meghna P MansukhaniVirend K Somers
Nov 21, 2018·Paediatrics & Child Health·Silviu GrisaruLorraine A Hamiwka
Sep 5, 2019·Journal of Clinical Medicine·Cesare CuspidiGiuseppe Mancia
Nov 17, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Susan Halbach

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