Jun 1, 2016

Age-Related Differences in the Modulation of Small-World Brain Networks during a Go/NoGo Task

Frontiers in Aging Neuroscience
Xiangfei HongShanbao Tong

Abstract

Although inter-regional phase synchrony of neural oscillations has been proposed as a plausible mechanism for response control, little is known about the possible effects due to normal aging. We recorded multi-channel electroencephalography (EEG) from healthy younger and older adults in a Go/NoGo task, and examined the aging effects on synchronous brain networks with graph theoretical analysis. We found that in both age groups, brain networks in theta, alpha or beta band for either response execution (Go) or response inhibition (NoGo) condition showed prominent small-world property. Furthermore, small-world property of brain networks showed significant differences between different task conditions. Further analyses of node degree suggested that frontal-central theta band phase synchrony was enhanced during response inhibition, whereas during response execution, increased phase synchrony was observed in beta band over central-parietal regions. More interestingly, these task-related modulations on brain networks were well preserved and even more robust in older adults compared with younger adults. Taken together, our findings not only suggest that response control involves synchronous brain networks in functionally-distinct frequ...Continue Reading

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References

Mentioned in this Paper

Coronal
Electroencephalography
Neuroma
Brain
Executive Function
Theoretical Study
Theta Rhythm
Biologic Preservation
RTN4 wt Allele
Parietal Region

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