Age-related differences in the structural complexity of subcortical and ventricular structures

Neurobiology of Aging
Christopher R Madan, Elizabeth A Kensinger


It has been well established that the volume of several subcortical structures decreases in relation to age. Different metrics of cortical structure (e.g., volume, thickness, surface area, and gyrification) have been shown to index distinct characteristics of interindividual differences; thus, it is important to consider the relation of age to multiple structural measures. Here, we compare age-related differences in subcortical and ventricular volume to those differences revealed with a measure of structural complexity, quantified as fractal dimensionality. Across 3 large data sets, totaling nearly 900 individuals across the adult lifespan (aged 18-94 years), we found greater age-related differences in complexity than volume for the subcortical structures, particularly in the caudate and thalamus. The structural complexity of ventricular structures was not more strongly related to age than volume. These results demonstrate that considering shape-related characteristics improves sensitivity to detect age-related differences in subcortical structures.


Jan 13, 2018·Aging & Mental Health·Christopher R Madan
Jan 24, 2018·The European Journal of Neuroscience·Christopher R Madan, Elizabeth A Kensinger
Jun 13, 2019·Brain Informatics·Christopher R Madan
Jan 6, 2017·Brain Informatics·Christopher R Madan, Elizabeth A Kensinger
Aug 22, 2017·Frontiers in Human Neuroscience·Christopher R Madan
Mar 30, 2018·Frontiers in Aging Neuroscience·Alexis M BullockJennifer J Heisz
Mar 25, 2020·Journal of Clinical Medicine·Enrico CollantoniAngela Favaro
May 12, 2017·F1000Research·Zachariah Reagh, Michael Yassa
Apr 5, 2018·Scientific Reports·Gernot ReishoferGuilherme Wood
Dec 13, 2019·BioMed Research International·Congsheng LiTongning Wu
Oct 14, 2020·Neurobiology of Aging·Andrew J CarradusChristopher R Madan

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