Age-related differences in the use of guideline-recommended medical and interventional therapies for acute coronary syndromes: a cohort study

Journal of the American Geriatrics Society
Andreas Wolfgang SchoenenbergerAcute Myocardial Infarction in Switzerland Plus Investigators

Abstract

To compare the use of guideline-recommended medical and interventional therapies in older and younger patients with acute coronary syndromes (ACSs). Prospective cohort study. Fifty-five hospitals in Switzerland. Eleven thousand nine hundred thirty-two patients with ACS enrolled between March 1, 2001, and June 30, 2006. ACS definition included ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), and unstable angina pectoris (UA). Use of medical and interventional therapies was determined after exclusion of patients with contraindications and after adjustment for comorbidities. Multivariate logistic regression models were used to calculate odds ratios (ORs) per year increase in age. Elderly patients were less likely to receive acetylsalicylic acid (OR=0.976, 95% confidence interval (CI)=0.969-0.980) or beta-blockers (OR=0.985, 95% CI=0.981-0.989). No age-dependent difference was found for heparin use. Elderly patients with STEMI were less likely to receive percutaneous coronary intervention (PCI) or thrombolysis (OR=0.955, 95% CI=0.949-0.961). Elderly patients with NSTEMI or UA less often underwent PCI (OR=0.943, 95% CI=0.937-0.949). Elderly patients across the whole spectru...Continue Reading

References

Oct 1, 1967·The American Journal of Cardiology·T Killip, J T Kimball
Aug 31, 2001·Journal of the American College of Cardiology·R H MehtaH M Krumholz
Apr 12, 2003·The American Journal of Medicine·Saif S RathoreHarlan M Krumholz
Oct 29, 2003·Archives of Internal Medicine·Christopher B GrangerUNKNOWN Global Registry of Acute Coronary Events Investigators
Mar 12, 2004·Journal of the American College of Cardiology·David A HalonBasil S Lewis
Apr 6, 2004·The American Journal of Medicine·David A AlterAndreas Laupacis
Nov 9, 2005·Journal of the American Geriatrics Society·Roy L SoizaAllister D Hargreaves
Jan 31, 2006·American Heart Journal·Raymond T YanUNKNOWN Canadian Acute Coronary Syndromes (ACS) Registry Investigators
Jun 17, 2006·Journal of the American Geriatrics Society·Andreas W Schoenenberger, Andreas E Stuck
Jul 15, 2006·International Journal of Cardiology·Julio A ChirinosSimon Chakko

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Citations

May 17, 2011·Zeitschrift für Gerontologie und Geriatrie·P BahrmannC C Sieber
Jun 17, 2011·Zeitschrift für Gerontologie und Geriatrie·A BahrmannP Oster
Nov 26, 2009·European Heart Journal·Petr WidimskyUNKNOWN European Association for Percutaneous Cardiovascular Interventions
Sep 13, 2011·Annals of Intensive Care·Yên-Lan NguyenBertrand Guidet
Sep 13, 2013·Journal of Cardiovascular Disease Research·Emad AhmedJassim Al Suwaidi
Apr 22, 2014·The American Journal of Emergency Medicine·Andreas W SchoenenbergerAristomenis Exadaktylos
Nov 8, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Andreas W SchoenenbergerPaul Erne
May 28, 2014·Heart·Mauro Di BariUNKNOWN Acute Myocardial Infarction in Florence 2 (AMI Florence-2) Working Group
Oct 25, 2014·BMC Medical Education·Adrian O GoeldlinAndreas W Schoenenberger
May 4, 2015·Emergency Medicine Journal : EMJ·Claudio MorettiFiorenzo Gaita
Jan 14, 2016·European Heart Journal·Andreas W SchoenenbergerUNKNOWN AMIS Plus Investigators
May 29, 2012·The American Journal of Cardiology·Frances O WoodCindy L Grines
Jul 6, 2012·Medicina intensiva·A Padilla-SerranoJ H de Gea-García
Jul 14, 2010·Annals of Emergency Medicine·Nikolaos SamarasGabriel Gold
Nov 6, 2009·Revista española de cardiología·Ramón López-PalopVicente Bertomeu-Martínez
Sep 29, 2009·European Journal of Internal Medicine·Andreas PerrenClaudio Marone
Sep 29, 2009·European Journal of Internal Medicine·Andreas W SchoenenbergerPaul Erne
Nov 26, 2008·The American Journal of Medicine·Philip UrbanUNKNOWN AMIS Plus Investigators
Mar 13, 2016·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Holli A DeVonJean C McSweeney
Dec 15, 2015·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·Abder Rahim Akroute, Terese Bondas
Sep 4, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ute AmannChrista Meisinger
Jun 3, 2015·European Journal of Internal Medicine·Paul ErneUNKNOWN AMIS Plus Investigators
Mar 17, 2015·The American Journal of Cardiology·Fabio MangiacapraGermano Di Sciascio
Mar 20, 2010·JACC. Cardiovascular Interventions·Sanneke P M de BoerUNKNOWN Primary Coronary Angioplasty Versus Thrombolysis-2 (PCAT-2) Trialists Collaborators Group
Sep 19, 2016·Journal of the American Medical Directors Association·Pavla CermakovaDorota Religa
Jan 21, 2017·Journal of Cardiovascular Medicine·Dragana RadovanovicPaul Erne
Feb 15, 2015·European Heart Journal. Acute Cardiovascular Care·Andreas W SchoenenbergerChristian Mueller
Sep 26, 2013·European Heart Journal. Acute Cardiovascular Care·Dragana RadovanovicUNKNOWN AMIS Plus Investigators
Apr 24, 2018·Journal of the American Geriatrics Society·Julien TurkGuillaume Debaty

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