Age-related effect of aerobic exercise training on antioxidant and oxidative markers in the liver challenged by doxorubicin in rats

Free Radical Research
Mehdi AhmadianAnthony S Leicht

Abstract

The aims of the current study were to investigate the oxidant and antioxidant status of liver tissue challenged by doxorubicin and to examine the possible protective effects of aerobic exercise on doxorubicin-induced oxidative stress. Seventy-two rats were divided into three age groups (Young, Adult, and Elderly) with three treatment subgroups consisting of eight rats per age group: doxorubicin, aerobic exercise + doxorubicin, and aerobic exercise + saline. The experimental groups performed regular treadmill running for 3 weeks. Doxorubicin was administered by i.p. injection at a dosage of 20 mg kg-1 while the aerobic exercise + saline group received saline of a comparable volume. Heat shock protein 70, malondialdehyde, glutathione peroxidase, and protein carbonyl were determined from the liver homogenates following the intervention period. Treatment with doxorubicin induced hepatotoxicity in all groups with lower values of oxidative stress in young compared with the older groups. The inclusion of aerobic exercise training significantly increased heat shock protein 70 and antioxidant enzyme levels (glutathione peroxidase) whereas it decreased oxidative stress biomarkers (malondialdehyde and protein carbonyl) for all age groups....Continue Reading

References

Jul 23, 1999·Medicine and Science in Sports and Exercise·S K PowersC Leeuwenburgh
Mar 29, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·P V Lakshmana RaoP C Jatav
Oct 8, 2005·Journal of Applied Physiology·Adam J ChiccoReid Hayward
Apr 10, 2007·Archives of Medical Research·Murat YagmurcaAhmet Songur
Oct 28, 2008·Mutation Research·Lucia Migliore, Fabio Coppedè
Feb 9, 2010·Medicine and Science in Sports and Exercise·Peter T CampbellCornelia M Ulrich
Dec 25, 2010·Revista do Colégio Brasileiro de Cirurgiões·José Ulisses de Souza MeloPaulo Roberto Leitão de Vasconcelos
Jan 19, 2011·Allergologia et immunopathologia·Ece OnurHasan Yüksel
Mar 8, 2011·International Journal of Toxicology·Valiollah Dabidi RoshanJonathan Myers
Jun 4, 2011·International Journal of Cardiology·António AscensãoJosé Magalhães
Oct 21, 2011·European Journal of Applied Physiology·Ronald J MaughanPhillip Watson
May 10, 2012·Journal of the National Cancer Institute·Rachel Ballard-BarbashCatherine M Alfano
Oct 9, 2012·Journal of Applied Physiology·Bradley J BehnkeMichael D Delp
Oct 30, 2012·Nature Medicine·Sui ZhangEdward T H Yeh
Dec 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Jaroslaw DudkaMarek Murias
Jan 3, 2013·The Journal of Pharmacy and Pharmacology·Oktay TacarCrispin R Dass
May 23, 2013·American Journal of Physiology. Endocrinology and Metabolism·Vernon W DolinskyJason R B Dyck
Nov 7, 2013·Toxicology and Industrial Health·Rafet MeteTarkan Yetisyigit
Nov 26, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohamed A El-Moselhy, Azza A K El-Sheikh
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ailin AlishahiMehdi Hedayyati
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Oct 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alisa UmanskayaAndrew R Marks
Dec 17, 2014·Life Sciences·Christiano Robles Rodrigues AlvesPatricia Chakur Brum
May 18, 2016·Current Treatment Options in Cardiovascular Medicine·Umberto Campia, Ana Barac
Jul 19, 2017·Journal of Dietary Supplements·Temidayo Olutayo OmobowaleMomoh Audu Yakubu
Jan 1, 2004·Comprehensive Reviews in Food Science and Food Safety·J LeeD B Min

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Citations

Jan 11, 2019·Medicine and Science in Sports and Exercise·J Matthew HinkleyAshley J Smuder
Aug 29, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ashley J Smuder

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