Age-related effects of DHEA on peripheral markers of oxidative stress

Cell Biochemistry and Function
Maria Helena Vianna Metello JacobMaria Flavia Marques Ribeiro

Abstract

Ageing is an inevitable biological process characterized by a general decline in various physiological functions. DHEA and DHEAS levels are maximal between the second and third life decades, then start to decline 2% per year, leaving a residual of 10-20% of the peak production by the eighth decade. Erythrocytes are exposed to frequent oxidative stress due to the oxygen radicals continuously generated by haemoglobin auto-oxidation. We investigated DHEA chronic (10 mg/kg, subcutaneously, for 5 weeks) effects over oxidative stress markers in erythrocytes of male Wistar rats of 3, 13 and 18 month-old. In the 13 month-old group, we found increased lipid peroxidation (LPO), superoxide dismutase (SOD), glutathione-S-transferase and catalase activities when compared to the other age groups. DHEA produced a marked increase in LPO of 13 month-old group when compared to its control. DHEA exerted this pro-oxidant effects in all ages studied, especially in age 13 month-old. It seems that at 13 month-old there would be an important depletion of some specific anti-oxidant in order to determine such susceptibility to DHEA effects. Since this approach allows a minimally invasive assessment, it would be useful as a routine method in human clinic...Continue Reading

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Aug 25, 2009·Steroids·Maria Helena Vianna Metello JacobMaria Flavia Marques Ribeiro

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Citations

Jul 13, 2013·Trends in Endocrinology and Metabolism : TEM·Yael YanivSteven J Sollott
Oct 25, 2011·The British Journal of Nutrition·Javier Díaz-CastroMargarita S Campos
Nov 12, 2010·Reproductive Biology and Endocrinology : RB&E·Norbert GleicherDavid H Barad
Aug 19, 2011·Reproductive Biology and Endocrinology : RB&E·Norbert GleicherDavid H Barad
May 19, 2011·Cell Biochemistry and Function·A S R AraujoA Belló-Klein
Jan 7, 2018·Sports Medicine - Open·Fatima Al-KhelaifiMohamed A Elrayess
Apr 13, 2021·Archives of Gerontology and Geriatrics·Mohammad Murtaza MehdiPrabhakar Singh
Sep 14, 2010·Experimental Gerontology·Maria Helena Vianna Metello JacobAdriane Belló-Klein

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