Nov 1, 1975

Age related effects of furosemide in the rat

Archives Internationales De Pharmacodynamie Et De Thérapie
J ZaumseilH Bräunlich


Furosemide (6 mg/kg i.p.) increases the renal excretion of water, osmotic active substances, sodium and chloride in 5 to 33 day old rats more than in adults. The dose-response-relations are the same in rats of all age groups: 6 mg/kg of furosemide i.p. are very effective, an increase in dose to 30-60 mg/kg i.p. is not followed by a significantly higher efficacy. The increase in the renal excretion of potassium, hydrogen ions, ammonium and hydrogen carbonate by furosemide is also small in young rats.

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Mentioned in this Paper

Chloride Ion Level
Renal Elimination
Salix - substance
Chloride Measurement

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