Age-related electrophysiological and histological changes in rabbit hearts: age-related changes in electrophysiology

International Journal of Cardiology
M GottwaldS Dhein

Abstract

Because of the known higher incidence of cardiac arrhythmia in aged patients we tried to define the underlying arrhythmogenic substrate by quantifying those electrophysiological alterations in aged rabbit hearts, which are commonly believed to be arrhythmogenic, relating them to histological findings in the same hearts. This is the first investigation that analyses the effect of ageing on the epicardial excitation spreading. Isolated hearts from young (ten weeks) and old (1.5-2 years) white New Zealand rabbits were perfused according to the Langendorff-technique, submitted to epicardial potential mapping for 60 min and investigated histologically. Electrophysiological data in aged hearts showed a) a higher variability of the activation pattern, b) an increased dispersion of the epicardial potential duration; c) a prolongation of the AV-conduction time and of the duration of the epicardial activation signal, which was fractionated in aged hearts. Histological findings showed extensive incorporation of fat cells and connective tissue in ventricular and AV-node tissues, which may explain the prolonged conduction time, and a marked hypertrophy of the ventricular myocytes. The observed high dispersion, the broadened and fractionated...Continue Reading

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Citations

Sep 5, 2002·Clinical and Experimental Pharmacology & Physiology·Harvey R WeissPeter M Scholz
May 15, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jieh-Neng WangLi-Jen Lin
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Jan 7, 2016·Frontiers in Physiology·Katja BlankeAida Salameh
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Nov 19, 2014·Frontiers in Physiology·Stefan DheinFriedrich-Wilhelm Mohr
Oct 14, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Stefano RossiEmilio Macchi
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Sep 6, 2002·The American Journal of Geriatric Cardiology·Fred M KusumotoNora Goldschlager
Feb 7, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Leroy L CooperGideon Koren

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