Age-related endocrine dysfunction in nonhuman primates

Annals of the New York Academy of Sciences
Nadezhda D Goncharova, Boris A Lapin

Abstract

Peculiarities of functioning of some parts of the endocrine system (the pineal gland, pancreatic gland, hypothalamic-pituitary-adrenal axis, and hypothalamic-pituitary-testicular axis) in an aging nonhuman primate model (Papio hamadryas and Macaca mulatta) are described in this article. It has been established that basal activity of some endocrine functions (glucocorticoid, corticotropic, pancreatic, male estradiol producing) varies little with age. Other functions significantly decrease (DHEA/DHEAS-producing, pineal, testicular) or increase (male gonadotropic) with age. In contrast with basal activity, pronounced age-related changes in response to specific stimuli were detected in all endocrine functions. Old baboons and rhesus monkeys exhibited a delay of the normalization of the pituitary-testicular axis, adrenal cortex, and pancreatic gland function after their activation in response to specific stimuli, such as LHRH, CRH, ACTH, and glucose. Old monkeys also demonstrate decreased HPA axis sensitivity to glucocorticoid regulation by negative feedback and the HPT axis to inhibitory effect of prolonged administration of LHRH agonist. Age-related changes in reactions of endocrine functions in response to specific stimulating an...Continue Reading

References

Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·J M Kaufman, A Vermeulen
Jan 1, 1995·Neurobiology of Aging·M H Bigham, M S Lidow
Jun 28, 2000·Journal of Medical Primatology·N D Goncharova, B A Lapin
Jun 5, 2002·Mechanisms of Ageing and Development·Nadezhda D Goncharova, Boris A Lapin
Dec 10, 2002·Neuroscience and Biobehavioral Reviews·Alan Peters
Jun 13, 2003·Bulletin of Experimental Biology and Medicine·N D GoncharovaV Kh Khavinson

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Citations

Feb 26, 2013·Menopause : the Journal of the North American Menopause Society·Alan J ConleyBill L Lasley
Mar 3, 2005·Neuroendocrinology·Russell D RomeoBruce S McEwen
Mar 14, 2014·The Journal of Endocrinology·R PrasadL A Metherell
Mar 11, 2006·Médecine sciences : M/S·Martine Perret, Fabienne Aujard
Jul 16, 2005·Experimental Gerontology·Martine Perret, Fabienne Aujard
Aug 2, 2011·Ageing Research Reviews·S LanguilleF Aujard
Feb 13, 2016·Veterinary Pathology·E S DidierM J Kuroda
Apr 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Melissa Emery ThompsonMartin N Muller
Aug 14, 2020·Animals : an Open Access Journal From MDPI·Jessica C WhithamLance J Miller

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