Age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorders: special references to lymphomas surrounding this newly recognized clinicopathologic disease

Cancer Science
Yoshie ShimoyamaShigeo Nakamura

Abstract

Epstein-Barr virus (EBV) is associated with some disease entities of malignant lymphomas, including Burkitt lymphoma, Hodgkin lymphoma, immunodeficiency-associated lymphoproliferative disorders (LPD), and a part of diffuse large B-cell lymphoma. We have recently identified a series of elderly patients with EBV-associated (or EBV(+)) B-cell LPD (B-LPD) showing similarities in many respects to immunodeficiency-associated LPD, although no evidence of underlying immunodeficiency was found. Therefore, the nosological category of senile or age-related EBV(+) B-LPD has been proposed for those patients. A larger series of patients with this disease revealed that the relative ratios of such EBV(+) B-LPD to all diffuse large B-cell lymphoma cases were higher with increasing with age, reaching a peak (20-30%) at > or =90 years of age, with a median of 71 years, providing additional evidence for our assertion that this disease may be related to immunological deterioration as a result of the aging process. This new disease entity is characterized pathologically by centroblasts, immunoblasts, and Hodgkin and Reed-Sternberg-like giant cells with a varying degree of reactive components, often posing therapeutic and diagnostic problems for hema...Continue Reading

References

Feb 7, 1997·International Journal of Cancer. Journal International Du Cancer·S L GlaserA Claviez
Feb 2, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T RüdigerH K Müller-Hermelink
Nov 24, 1999·The New England Journal of Medicine·R KüppersK Rajewsky
Mar 16, 2002·Journal of Clinical Pathology·S A PileriH Stein
Oct 31, 2002·British Journal of Haematology·Gail L StarkUNKNOWN Northern Region Lymphoma Group
Dec 28, 2002·The American Journal of Surgical Pathology·Takashi OyamaShigeo Nakamura
Feb 4, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K J FlavellP G Murray
Mar 22, 2003·Lancet·Lynny Yung, David Linch
Sep 30, 2003·Medical Oncology·Rose-Marie Amini, Gunilla Enblad
Oct 3, 2003·Nature Reviews. Immunology·Ralf Küppers
Apr 17, 2004·British Journal of Haematology·Maher K GandhiRajiv Khanna
Sep 7, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Naoko AsanoShigeo Nakamura
Oct 25, 2006·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshie ShimoyamaShigeo Nakamura
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takashi OyamaShigeo Nakamura

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Citations

May 12, 2009·International Journal of Hematology·Hitoshi OhnoKotaro Isoda
Apr 28, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Santiago Montes-MorenoMiguel A Piris
Jun 12, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J I CohenE S Jaffe
Jan 14, 2010·The American Journal of Dermatopathology·Blanca MartinAlistair Robson
Dec 27, 2011·The American Journal of Dermatopathology·Pablo ZoroquiainJosé R Valbuena
Nov 22, 2013·The American Journal of Dermatopathology·Angel Fernandez-Flores
Feb 16, 2010·The American Journal of Surgical Pathology·Stefan D DojcinovElaine S Jaffe
Feb 26, 2010·Immunity & Ageing : I & a·Eric J YagerMarcia A Blackman
May 28, 2010·Journal of Clinical and Experimental Hematopathology : JCEH·Tsutomu TakahashiHiroto Ishikura
Aug 2, 2012·Archives of Pathology & Laboratory Medicine·Alexandra C Hristov
Mar 25, 2014·Case Reports in Hematology·Jacob P SmeltzerThomas E Witzig
Jun 24, 2010·Revue des maladies respiratoires·J TracletJ-F Cordier
Mar 4, 2009·Leukemia & Lymphoma·Hannah H Wong, Jun Wang
Nov 16, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chen ChanKung-Chao Chang
Oct 22, 2015·American Journal of Clinical Pathology·Maria Raffaella AmbrosioLorenzo Leoncini
Feb 4, 2016·Expert Review of Anticancer Therapy·Ana Battle-LopezMiguel A Piris
Feb 1, 2013·International Journal of Cancer. Journal International Du Cancer·Liang WuGeorge Klein
Oct 4, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Thierry RauschLaurence de Leval
Apr 16, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Aysegul UnerMustafa Benekli
May 3, 2014·International Journal of Cancer. Journal International Du Cancer·M CohenP A Chabay
May 8, 2013·Blood·Chi Young OkKen H Young
Dec 6, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Y HongW S Kim
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Olga PozdnyakovaJeffery L Kutok

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