Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of senescence accelerated mouse prone/8 mice is modulated by anti-Alzheimer's disease drugs

Neuroscience
G-R ZhangY-X Zhang

Abstract

Senescence-accelerated mouse (SAM) prone/8 (SAMP8) is a good animal model to investigate the fundamental mechanisms of age-related learning and memory deficits such as Alzheimer's disease (AD) at the gene and protein levels, and SAM resistant/1 (SAMR1) is its normal control. Calcium/calmodulin-dependent protein kinase II-alpha (CaMKIIalpha) is one of the most abundant subunits of calcium/calmodulin-dependent protein kinase II in cerebral cortex and hippocampus, and is closely linked to AD. In this study, we used real time fluorescence quantitative PCR (RT-PCR) and Western blot techniques to examine the expression of CaMKIIalpha mRNA and protein in the cerebral cortex and hippocampus of SAMP8 both with aging and following treatment with anti-AD drugs (for example, natural product huperzine A (HupA) and traditional Chinese medicinal prescription Liu-Wei-Di-Huang decoction (LW), Ba-Wei-Di-Huang decoction (BW), Huang-Lian-Jie-Du decoction (HL), Dang-Gui-Shao-Yao-San (DSS) and Tiao-Xin-Fang decoction (TXF)). The results showed that the levels of both CaMKIIalpha mRNA and protein decreased significantly in the cerebral cortex of SAMR1 with aging, but increased significantly in the cerebral cortex of SAMP8. Compared with age-matched S...Continue Reading

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Citations

Oct 20, 2009·Journal of Molecular Neuroscience : MN·Shao-Chun ChenHsiang-Fu Kung
Jul 22, 2015·Experimental Brain Research·Sakiko TaniguchiKoichi Ito
Sep 24, 2016·Journal of Alzheimer's Disease : JAD·Lan GuoHeng Du
Jan 10, 2017·Ageing Research Reviews·Mahesh Shivarama Shetty, Sreedharan Sajikumar
Jun 29, 2017·Occupational Therapy in Health Care·Seyed Alireza DerakhshanradBahareh Zeynalzadeh Ghoochani
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Weidong PanTe Liu
Oct 22, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kaori IshikawaKazuto Nakada
Apr 4, 2021·International Journal of Molecular Sciences·Ming-Hui YangYu-Chang Tyan
May 1, 2021·International Journal of Molecular Sciences·Kinga SałaciakKarolina Pytka

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