Age-related histopathological lesions in the Mongolian gerbil ventral prostate as a good model for studies of spontaneous hormone-related disorders

International Journal of Experimental Pathology
Silvana G P CamposSebastião Roberto Taboga

Abstract

The Meriones unguiculatus (Mongolian) gerbil has demonstrated significant prostatic responses to hormonal treatments, and to drugs against human prostatic hyperplasia. Spontaneous neoplasia develops in the older animals. Thirty gerbils (age 18 months) were divided into non-affected and prostatic lesion bearers and the prostate lesions were evaluated morphologically, immunohistochemically and quantitatively. The most frequent changes were in epithelial sites and, namely prostatic intraepithelial neoplasias, microinvasive carcinomas and adenocarcinomas. In the stromal compartment, cellular hyperplasia, when verified, was always associated with the sites of anomalous epithelium. Additionally, larger deposition of collagen fibrils, generating stromal fibrosis, was found in all the old gerbils analysed. The quantitative analysis showed that prostatic tissue proportions differed in altered areas, being specific for each lesion type. Isolated nuclear and nucleolar parameters were not effective in diagnosing the malign potential of lesions. However, the cellular proliferation and death indexes indicated larger cellular turnover in invasive lesions such as carcinomas. With these analyses, it could be verified that old gerbils present hi...Continue Reading

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Citations

Nov 15, 2007·International Journal of Experimental Pathology·Wellerson Rodrigo ScaranoSebastião Roberto Taboga
Dec 6, 2016·International Journal of Experimental Pathology·Luiz R Falleiros-JúniorPatrícia S L Vilamaior
Apr 1, 2010·International Journal of Experimental Pathology·Silvana G P CamposSebastião R Taboga
Jul 1, 2009·International Journal of Experimental Pathology·Ji Ke LiHai Tian
Apr 23, 2014·Microscopy Research and Technique·Bruno Domingos Azevedo SanchesSebastião Roberto Taboga
Mar 18, 2020·Cell Biology International·Nayara F C CastroPatrícia S L Vilamaior
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Sebastião Roberto TabogaRejane Maira Góes
Jun 15, 2021·The Prostate·Nayara Fernanda da Costa CastroPatrícia Simone Leite Vilamaior
Jul 14, 2021·The Prostate·Bruno D A SanchesSebastião R Taboga
Jul 22, 2021·Cell Biology International·Ellen Cristina Rivas LeonelSebastião Roberto Taboga

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