Age related impairment in phosphatidylinositol breakdown of polymorphonuclear granulocytes

FEBS Letters
T FülöpA Leövey

Abstract

It is well known that with aging the immune response decreases. Most of the effector functions occur through specific receptors. Thus, we investigated the effects of various stimulants, acting through receptors or directly through the GTP-binding Gi protein, on phosphatidylinositol breakdown in PMNLs of young and elderly subjects and try to modulate it. A marked decrease in inositol phosphate (IP1, IP2, IP3) formation in PMNLs of elderly was found under FMLP stimulation when compared to that of young subjects. Neither GTP gamma S, nor AIF4- could induce an increase of IP3 in PMNLs of elderly comparable to that of young subjects. The results suggest that at least an alteration exists at the GTP-binding Gi protein level, as well as in the mechanism of linkage of the receptor to the G protein.

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Citations

Jan 1, 1995·Journal of Bioluminescence and Chemiluminescence·A C McCaffertyM E McMurdo
Oct 1, 1993·Mechanisms of Ageing and Development·I SeresT Fülöp
Apr 26, 2003·Mechanisms of Ageing and Development·Anja Kristina Schröder, Lothar Rink
Apr 1, 1997·Mechanisms of Ageing and Development·G FauryJ Verdetti
Feb 7, 2002·Experimental Gerontology·M E KlutJ C Hogg
Oct 8, 1998·Experimental Gerontology·P C BragaC Vergani
Jun 27, 2002·Seminars in Cancer Biology·Tamas Fülöp, Anis Larbi
Nov 24, 2001·Mutation Research·Mariann HarangiGyörgy Paragh
Jan 5, 1993·Annals of the New York Academy of Sciences·T FülöpJ P Despont
May 22, 2001·Clinical and Experimental Immunology·E AlvarezC Santa-María
Jan 1, 1992·Archives of Gerontology and Geriatrics·F LicastroR Conte
Aug 30, 2005·Metabolism: Clinical and Experimental·Ildiko SeresGyorgy Paragh
Jul 23, 2004·Aging Cell·Tamas FulopGilles Dupuis

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