PMID: 12757616May 22, 2003Paper

Age-related increase of peripheral CD4+ CD8+ double-positive T lymphocytes in cynomolgus monkeys: longitudinal study in relation to thymic involution

Immunology
Won-Woo LeeY Yoshikawa

Abstract

The age-related increase of peripheral CD4+ CD8+ double-positive (DP) T cells in cynomolgus monkeys has been reported previously. Because the percentage of DP T cells in cynomolgus monkeys increases abruptly in parallel with the thymic involution occurring at around 11 years of age, it was suggested that thymic involution was associated with this increase. Therefore, a longitudinal study was carried out over 5 years to clarify the exact time when DP T lymphocytes start to increase in relation to the thymic involution. Twelve cynomolgus monkeys at 6 years of age were classified into three groups, based on their percentage of DP T cells, as follows: DP-High (>5% DP T cells); DP-Middle (1-5% DP T cells); and DP-Low (<1% DP T cells). In the DP-High group, the percentage of DP T cells showed an abrupt increase, of >10%, in monkeys at 7 years of age, and the prevalence of this subset correlated with a distinctive increase in the percentage of memory T cells (CD4+ CD29(high), CD8+ CD28-), indicating an association with the maturation of immune function, including thymic involution. To assess the thymic function, the coding joint of T-cell receptor excision circles (cjTREC) levels in sorted T cells were analysed by polymerase chain rea...Continue Reading

References

Jul 1, 1986·The Journal of Experimental Medicine·L L LanierJ H Phillips
Dec 1, 1994·Clinical Immunology and Immunopathology·E TonuttiA Colombatti
Apr 1, 1994·The Journal of Experimental Medicine·D F Tough, J Sprent
Jan 1, 1993·Advances in Immunology·M C Miceli, J R Parnes
Jun 25, 1998·Developmental and Comparative Immunology·K H NamY Yoshikawa
Nov 17, 1998·Experimental Animals·K H NamY Yoshikawa
Dec 30, 1999·Veterinary Immunology and Immunopathology·F A Zuckermann
Aug 12, 2000·Journal of Clinical Immunology·R Aspinall, D Andrew
Aug 22, 2000·The Journal of Experimental Medicine·C D Surh, J Sprent
Mar 15, 2001·Nature Immunology·P MarrackJ Kappler
Nov 21, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M D HazenbergJ J van Dongen

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Citations

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Nov 2, 2014·Journal of Leukocyte Biology·Nana H OvergaardJames W Wells
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sue StacyPeter H Dube

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