Age-related lesions in the cerebrum in middle-aged female cynomolgus monkeys

Toxicologic Pathology
Rinya KodamaHorishi Maeda

Abstract

Alzheimer's disease (AD) in humans is a progressive neurogenic disease that can be linked with such characteristic pathological findings in the cerebrum as senile plaques (SPs), neurofibrillary tangles (NFTs), cerebral amyloid angiopathy (CAA), and neuronal loss. In the present study, the authors investigated the age-related morphological changes in 12 middle-aged and 12 young cynomolgus monkeys. Low numbers of neurons and astrocytes in the hippocampal region in cynomolgus monkeys accompanied ageing, and there was a high number of microglial cells; however, no clearly neurotoxic abnormalities due to beta-amyloid were noted before the age of 20 years. The onset of SPs and CAA in the cerebrum in cynomolgus monkeys can occur before the age of 20 years. SPs were almost all categorized as diffuse plaques (DPs); they did not have amyloid cores and were unaccompanied by neuritic degeneration. In cynomolgus monkeys, SPs (DPs) occur before the appearance of CAA. From the above, it was concluded that cynomolgus monkeys showed pathological changes due to ageing similar to those related to Alzheimer's disease in humans, even before they were 20 years old.

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Citations

May 5, 2012·Journal of Neuroinflammation·Julia KoflerClayton A Wiley
Nov 6, 2015·Journal of Toxicologic Pathology·Kazumoto ShibuyaSeiji Otake
Aug 29, 2012·Journal of Medical Primatology·Di WuYu A Zhang
Jun 18, 2014·Toxicologic Pathology·Mark Timothy ButtGeorge L Foley
Oct 1, 2017·Clinical Science·Lieke JäkelMarcel M Verbeek
Jul 14, 2021·American Journal of Primatology·Carmen Freire-CoboPatrick R Hof

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Software Mentioned

MUSCOT
Soft Imaging System

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