Age-related loss of the responsiveness of the tuberoinfundibular dopaminergic neurons to prolactin in the female rat

Neuroendocrinology
M J Reymond

Abstract

In the old female rat the previous findings of a sustained reduction of the secretory activity of the hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons associated with a persistent hyperprolactinemia as well as the observation of a failure of the prolactin (PRL) short-loop feedback mechanism have been suggestive of an age-related loss of the responsiveness of the TIDA neurons to the stimulatory action of PRL. Yet the existence of significant impairments in the capacity of the neurons to respond to PRL could not be demonstrated in an earlier study using multiparous old rats in constant estrus compared to young nulliparous estrous rats. In the present study we have readdressed the issue using nulliparous old rats (24-26 months) compared to virgin young rats (4-5 months); two sets of old rats were studied which displayed distinct senile reproductive states, namely persistent diestrus or repetitive pseudopregnancy, and they were compared to young rats in diestrus or in repetitive pseudopregnancy, respectively. The secretory activity of the TIDA neurons was evaluated by measurement of dopamine biosynthesis in the neurons (DOPA accumulation in the median eminence after decarboxylase inhibition) and dopamine release into hyp...Continue Reading

Citations

Dec 15, 1993·Mechanisms of Ageing and Development·G L RossiR Neiger
Mar 1, 1992·Neurobiology of Aging·G L RossiM J Reymond
Jan 1, 1997·Brain Research Bulletin·P S MohankumarJ L Voogt
Mar 6, 2003·The Journal of Comparative Neurology·Hilda Liliana SánchezGustavo Oscar Zuccolilli
Nov 10, 2010·Physiology & Behavior·Vanessa MourlonValérie Daugé
Sep 16, 2006·Critical Reviews in Toxicology·A ShippC Van Landingham
Jul 30, 2020·Journal of Neuroendocrinology·Zsuzsanna BaradRosemary S E Brown
Oct 20, 2020·Physiological Reports·Susana Quirós CognuckJose Antunes-Rodrigues

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