Age-related low expression of HLA-DR molecules on monocytes of term and preterm newborns with and without signs of infection

Journal of Perinatology : Official Journal of the California Perinatal Association
Alexandra BirlePeter Gessler

Abstract

Presentation of human leucocyte antigen (HLA) molecules is an important part of an efficient immune response. Since bacterial infections are more common in newborns, we hypothesized that the level of HLA-DR expression may influence the host defense system. HLA-DR expression on monocytes was examined by flow cytometry during the first week of life of term and preterm neonates with and without signs of infection and of adults. HLA-DR expression of term and preterm newborns with or without signs of infection was lower compared with adults during the first day of life (p<0.0001). Prematurity correlates with lower expression in neonates with gestational age less than 32 weeks (p=0.0008). HLA-DR expression in neonates with signs of infection was decreased compared to healthy neonates (p=0.0196). Maternal conditions such as preeclampsia, prenatal treatment with steroids and mode of delivery had no influence on the expression of HLA-DR. In contrast, newborns with respiratory distress syndrome but without signs of infection showed reduced HLA-DR expression (p=0.0370). Low HLA-DR expression on monocytes contributes to impaired neonatal host defense, especially in preterm neonates.

References

Mar 24, 1988·The New England Journal of Medicine·R B Johnston
Mar 1, 1987·European Journal of Pediatrics·N J Mathers, F Pohlandt
Sep 1, 1983·Pediatric Infectious Disease·H Peltola, C Holmberg
Dec 25, 1980·The New England Journal of Medicine·H O McDevitt
Jul 1, 1994·British Journal of Haematology·B ThilaganathanG Morgan
Oct 1, 1995·Cellular Immunology·L M SchwiebertS J Ono
Jan 1, 1995·Biology of the Neonate·A A El-MohandesI M Katona
Oct 23, 1997·Journal of Leukocyte Biology·M F GeertsmaP H Nibbering
Dec 1, 1995·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·K AsadullahH D Volk
May 12, 1998·Clinical Immunology and Immunopathology·B KampalathL Kass
Feb 19, 1999·Annals of Surgery·M DitschkowskiH Grosse-Wilde
Feb 24, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·J R McColmN McIntosh
Jul 7, 2000·The New England Journal of Medicine·P J Delves, I M Roitt
Aug 3, 2000·The New England Journal of Medicine·R Medzhitov, C Janeway
Sep 7, 2000·The New England Journal of Medicine·J Klein, A Sato
Sep 16, 2000·Intensive Care Medicine·A C Muller KoboldJ W Tervaert

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Citations

Dec 28, 2012·Pediatric Research·Anniina PalojärviSture Andersson
Feb 19, 2005·Pediatric Research·Thorsten W OrlikowskyChristian F Poets
Jan 5, 2011·The Journal of Nutritional Biochemistry·Richard H SiggersPer T Sangild
Dec 8, 2009·Human Immunology·Alicia PérezMa Angeles Muñoz-Fernández
Nov 24, 2004·Human Immunology·Laura DrohanElizabeth D Mellins
Jul 7, 2005·The Journal of Thoracic and Cardiovascular Surgery·Peter GesslerDavid Nadal
Apr 9, 2015·Cytometry. Part B, Clinical Cytometry·Richeek PradhanMitali Chatterjee
Mar 10, 2017·American Journal of Reproductive Immunology : AJRI·Florentina SavaBarna Vásárhelyi
Mar 24, 2018·The Pediatric Infectious Disease Journal·Navin P BoeddhaGertjan J Driessen
Jun 21, 2017·Journal of Leukocyte Biology·Emma de JongAndrew Currie
Mar 28, 2012·Pediatrics·Mallika AziziaDonald Peebles

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