Age-Related Macular Degeneration and Risk of Degenerative Dementia among the Elderly in Taiwan: A Population-Based Cohort Study

Ophthalmology
Der-Chong TsaiHsin-Bang Leu

Abstract

To investigate the relationship between age-related macular degeneration (AMD) and future development of Alzheimer's disease (AD) or senile dementia. A longitudinal case-control study using the Taiwan National Health Insurance Research Database. From 2001 to 2009, the newly diagnosed AMD cases aged ≥65 years in the database were recruited as the AMD cohort (n=4993). Of those, there were 540 with and 4453 without exudative AMD diagnoses. Subjects without any AMD, matched for age, gender, and time of enrollment, were randomly sampled as the control cohort (n=24,965) for comparison. Alzheimer's disease/senile dementia-free survival analysis was assessed using a Kaplan-Meier method. Cox proportional hazard regressions were performed to calculate the hazard ratios (HR) of AD or senile dementia for the 2 cohorts after adjusting for preexisting comorbidities and number of clinical visits. The first-ever diagnosis of AD or senile dementia during the observation period. Of the 29 958 sampled subjects, 1589 (5.3%) were diagnosed with AD or senile dementia during a mean follow-up period of 4.4 years, including 294 (5.9%) from the AMD cohort and 1295 (5.2%) from the control cohort. The incidence of AD or senile dementia was higher in patie...Continue Reading

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Citations

Aug 14, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Cecilia S LeePaul K Crane
Dec 26, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Yao-Lin LiuYen-Ching Chen
May 26, 2018·JAMA Ophthalmology·Gauthier AldebertVincent Daien
May 24, 2020·Journal of Alzheimer's Disease : JAD·Eric J SchwaberEleonora M Lad
Mar 19, 2019·Journal of Alzheimer's Disease : JAD·Cecilia S LeeUNKNOWN Adult Changes in Thought (ACT) Study
Dec 20, 2018·Current Opinion in Neurology·Carol Y CheungTien Y Wong
Apr 1, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Phillip H HwangAnnette L Fitzpatrick
May 28, 2021·JAMA Ophthalmology·Mariacristina ParravanoGianni Virgili
Aug 17, 2021·Journal of Alzheimer's Disease : JAD·Elżbieta KuźmaUlrich Thiem

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