Age-related mineralization heterogeneity changes in trabecular bone of the proximal femur

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
R D BloebaumErin L Whitaker

Abstract

Although there is extensive documentation in the literature regarding the importance of trabecular bone for proximal femoral integrity and fracture resistance, there remain gaps in our understanding of the basic mineral changes that may occur in trabecular bone attributable to aging. It is unclear what age-related changes take place in the trabecular bone of the proximal femur, a common fracture site in the elderly. It has been suggested that some explanation for conflicting reports on cancellous bone may be found at a microscopic level. The goal of this study was to document age-related changes in micromineralization in the proximal femur of Caucasian females using backscattered electron imaging technology. Proximal femurs were obtained from 11 young and 11 elderly females. Sections of bone from the superior and inferior neck and superior and inferior trochanter were analyzed in a scanning electron microscope using the backscatter technique to determine ash percent. Mean ash percent did not change with age in any of the four regions (P > 0.05). However, while the mean ash percent did not change, there was a dramatic increase in variability elderly age group and loss of mineral heterogeneity. This indicates that there are subpo...Continue Reading

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Citations

Feb 19, 2008·The British Journal of Nutrition·Jennifer A JamiesonHope A Weiler
Oct 5, 2013·Journal of the Mechanical Behavior of Biomedical Materials·M A BrennanL M McNamara
Jul 2, 2014·Journal of Structural Biology·John G SkedrosRoy D Bloebaum

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