Age-related mitochondrial DNA deletion in rat liver depends on dietary fat unsaturation

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
José L QuilesJosé Mataix

Abstract

We fed male Wistar rats lifelong on virgin olive (rich in the monounsaturated oleic acid) or sunflower (rich in the polyunsaturated linoleic acid) oil-based diets. At 6 and 24 months, liver mitochondria were analyzed for a mitochondrial DNA (mtDNA) deletion, reactive oxygen species, antioxidants, and ultrastructural alterations. An aging-related increase in the relative amount of the deletion was observed for both dietary groups, being higher in animals fed sunflower oil. Oxidative stress was lower in virgin olive oil-fed animals. Aging led to higher superoxide dismutase, catalase, and glutathione peroxidase activities and increased alpha-tocopherol and coenzyme Q. Mitochondria from aged animals fed sunflower oil exhibited a lower number of cristae and a higher circularity. Results suggest that the age-related increase of the relative amount of deleted mtDNA depends on fat unsaturation. Moreover, the studied mtDNA deletion was correlated with mitochondrial oxidative stress and ultrastructural alterations.

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Citations

Oct 19, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Enrique RocheJosé L Quiles
Feb 4, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucía Fernández del RíoJosé M Villalba
Aug 10, 2010·Mitochondrion·Hélène LemieuxPierre U Blier
Mar 23, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J López-MirandaN Yiannakouris
Oct 20, 2006·Experimental Gerontology·Rosario I BelloJosé M Villalba
Jul 15, 2015·The Journal of Nutritional Biochemistry·Camila Simonetti PaseMarilise Escobar Burger
Jul 30, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alfonso Varela-LopezJosé L Quiles
Jul 19, 2016·Experimental Gerontology·Carolina Sánchez-RodríguezRicardo Sanz-Fernández
Sep 2, 2016·BioFactors·Marta PiroddiFrancesco Galli
Oct 11, 2016·Journal of Agricultural and Food Chemistry·Amy Botta, Sanjoy Ghosh
Jun 28, 2019·British Journal of Pharmacology·Lukas SchwingshacklGeorg Hoffmann
Jul 3, 2021·International Journal of Molecular Sciences·Jose M Romero-MárquezJosé L Quiles
Oct 16, 2007·Journal of Agricultural and Food Chemistry·Yosra AlloucheGabriel Beltrán

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