PMID: 9436624Jan 22, 1998Paper

Age-related mitochondrial DNA deletions: effect of dietary restriction

Free Radical Biology & Medicine
C M KangB P Yu

Abstract

Results from quantitative PCR analysis of the frequency of deleted mitochondrial genomes in male Fischer 344 rats reveal an age-related rise in this molecular abnormality. We used this model to examine the ability of dietary restriction (DR) to prevent this potentially pathogenic change. DR prevented age-related increase in frequency of mitochondrial deletions in the liver. In contrast, however, DR had no effect on the age-related increase in deletion frequency in the brain. These data suggest that the effects of DR on age-related accumulation of mitochondrial DNA deletions may be tissue specific.

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