PMID: 36435Jul 1, 1979

Age-related mitochondrial lipoperoxidation in human skin

The Journal of Investigative Dermatology
F SerriT Galeotti

Abstract

Mitochondria were isolated from the epidermis of human subjects of different ages by a procedure that included pretreatment of the tissue with bacterial protease before homogenization. That epidermal mitochondria catalyze enzymatic lipid peroxidation in the presence of NADPH and chelated iron (ADP-Fe3+) is indicated by the production of malonaldehyde. The process does not appear to be influenced by age, and it is strongly enhanced in preparations containing a small amount of melanin.

References

Jan 1, 1984·Archives of Dermatological Research·S BorrelloF Serri

Related Concepts

Iron Chelating Agents
Endopeptidases
Senility
Proteolytic Enzyme
Malondialdehyde
Mitochondria
Lipid Peroxidation
Skin
NADP
Peroxides

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