PMID: 15374330Jul 1, 1993Paper

Age-related modifications of aorta and coronaries in the rabbit: a morphological and morphometrical assessment

Archives of Gerontology and Geriatrics
Augusto OrlandiL G Spagnoli

Abstract

Aging seems to be related to various vascular diseases, such as dissecting aneurysm and atherosclerosis. The nature of the relationship between aging and these vascular diseases has not been completely clarified. The goal of this study was to investigate, using morphological and morphometrical methods, the age related modifications of the arterial wall in rabbits of three different ages, evaluating separately two different vascular districts and the various aortic segments. Our results confirm that the most relevant age-related structural aortic changes were the increase of thickness, length, volume and diameter of the vessels, together with the development of an intimal thickening. The latter was diffuse in the aorta and focal in coronary vessels and it appears earlier in the aorta than in the coronaries, being absent in the coronaries of young rabbits. In addition, morphological and ultrastructural studies revealed the presence in aged rabbits of some marked intimal storage of a ground substance into intimal thickening of proximal aortic segments. Morphometric studies demonstrated an age-related decrease of aortic cellularity of tunica media and a parallel increase of the content of collagen and glycosaminoglycans, whereas el...Continue Reading

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Citations

Oct 17, 2015·International Journal of Molecular Sciences·Sara CasellaAugusto Orlandi
Apr 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·A OrlandiL G Spagnoli
Mar 28, 2017·Journal of Internal Medicine·M TesauroN Di Daniele
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ana M BrionesElisabet Vila
Dec 30, 2020·Experimental Gerontology·Yun Kyung JeonRobert T Mankowski
Feb 21, 2006·Atherosclerosis·Augusto OrlandiLuigi Giusto Spagnoli
Sep 1, 2007·Journal of the American Society of Hypertension : JASH·Edward G Lakatta

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