PMID: 2108443Apr 1, 1990Paper

Age-related modulatory activity by a cholinergic agonist on the growth hormone response to GH-releasing hormone in the rat

Proceedings of the Society for Experimental Biology and Medicine
G PanzeriV Locatelli

Abstract

The involvement of the cholinergic system in growth hormone (GH) secretion has acquired increased importance in the last few years. In rats, pretreatment with muscarinic cholinergic agonists potentiates the GH release induced by GH-releasing hormone (GHRH), via inhibition of somatostatin (SRIF) release from the hypothalamus. The aim of this study was to validate the use of cholinergic agonists to probe the functional activity of the hypothalamic SRIF system. It is known that hypothalamic SRIF displays an age-related increase in its functional activity; therefore, rats from 10 days to 29 months of age were used and challenged with GHRH following acute administration of pilocarpine, a cholinergic muscarinic agonist. Following administration of GHRH alone there was an age-related decline in GH responsiveness. Administration of pilocarpine potentiated the GH response to GHRH during the entire life-span of the rats, the only exception being 10-day-old rats in which the drug was without effect. Pilocarpine, though effective in potentiating the GH response to GHRH, did not restore, in senescent rats, GH stimulation to the level of that present in young (3-month old) or adult rats (8-month old). However, the drug was effective in rejuv...Continue Reading

Citations

Jun 1, 1992·Aging : Clinical and Experimental Research·D Cocchi
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Jan 1, 1997·Aging : Clinical and Experimental Research·E E MüllerD Cocchi

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