Age-related natural fertility outcomes in women over 35 years: a systematic review and individual participant data meta-analysis.

Human Reproduction
S J ChuaRik van Eekelen

Abstract

What is the rate of natural conception leading to ongoing pregnancy or livebirth over 6-12 months for infertile women of age ≥35 years? Natural conception rates were still clinically relevant in women aged 35 years and above and were significantly higher in women with unexplained infertility compared to those with other diagnoses. In recent years, increasing numbers of women have attempted to conceive at a later age, resulting in a commensurate increase in the need for ART. However, there is a lack of data on natural fertility outcomes (i.e. no interventions) in women with increasing age. A systematic review with individual participant data (IPD) meta-analysis was carried out. PubMed, MEDLINE, EMBASE, the Cochrane Library, clinicaltrials.gov were searched until 1 July 2018 including search terms 'fertility service', 'waiting list', 'treatment-independent' and 'spontaneous conception'. Language restrictions were not imposed. Inclusion criteria were studies (at least partly) reporting on infertile couples with female partner of age ≥35 years who attended fertility services, underwent fertility workup (e.g. history, semen analysis, tubal status and ovulation status) and were exposed to natural conception (e.g. independent of treat...Continue Reading

References

Aug 12, 1978·Lancet·P C Steptoe, R G Edwards
Dec 14, 1985·British Medical Journal·M G HullK M Desai
Mar 29, 2003·Science·Wolfgang LutzSergei Scherbov
Dec 7, 2005·Journal of Assisted Reproduction and Genetics·D J CahillE Corrigan
Sep 26, 2006·Human Reproduction·J W van der SteegUNKNOWN CECERM study group (Collaborative Effort for Clinical Evaluation in Reproductive Medicine)
May 6, 2008·Human Reproduction·M J C EijkemansJ D F Habbema
Jan 24, 2009·Human Reproduction·L LindborgA Strandell
Jul 11, 2009·Endocrine Reviews·F J BroekmansB C Fauser
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Jan 25, 2012·Human Reproduction·Marie WalschaertsPatrick Thonneau
Aug 6, 2013·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Karen WynterJane Fisher
Aug 29, 2013·Journal of Assisted Reproduction and Genetics·Michaël De BruckerMichel Camus
Mar 29, 2014·Human Reproduction·Marinus J C EijkemansEgbert R te Velde
Jul 18, 2015·Human Reproduction·J Dik F HabbemaEgbert R te Velde
Apr 25, 2017·Reproductive Biomedicine Online·Alexandra J BensdorpUNKNOWN CECERM study group
May 19, 2017·The New England Journal of Medicine·Kim DreyerBen W J Mol
Jun 22, 2017·Human Reproduction·UNKNOWN ESHRE Capri Workshop Group
Nov 9, 2017·Human Reproduction·Fernando Zegers-HochschildSheryl van der Poel
Apr 26, 2018·American Journal of Reproductive Immunology : AJRI·Tiina RantsiAila Tiitinen
Jun 14, 2019·Human Reproduction·R van EekelenD J McLernon

❮ Previous
Next ❯

Citations

Oct 31, 2020·Seminars in Reproductive Medicine·Rui WangMadelon van Wely
Sep 22, 2021·Acta Obstetricia Et Gynecologica Scandinavica·Tom G Tanbo, Peter Z Fedorcsak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Human Reproduction
Abha MaheshwariSiladitya Bhattacharya
Ginekologia polska
B GrzechocińskaL Marianowski
JAMA : the Journal of the American Medical Association
Sandra Ann Carson, Amanda N Kallen
Obstetrical & Gynecological Survey
Tarek A GelbayaLuciano G Nardo
Best Practice & Research. Clinical Obstetrics & Gynaecology
Ben Willem MolMadelon van Wely
© 2021 Meta ULC. All rights reserved