Age-related neural degeneration in nuclear-factor kappaB p50 knockout mice

Neuroscience
Z-Y LuL Wei

Abstract

Nuclear factor-kappaB is a transcription factor that regulates a variety of genes involved not only with immune and inflammatory responses, but also in cell survival. Nuclear-factor kappaB in the CNS is an area of current research interest; however, its role in age-related neural degeneration is obscure. The present study examines developmental degeneration changes in wild type and nuclear factor-kappaB p50 subunit knockout mice (p50-/-) using various morphological methodologies. P50-/- mice appeared normal at birth. At 6 and 10 months old, the body weight of p50-/- mice was significantly less than that of wild type mice and they started to die from aging. Consistently, terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end-labeling positive cells in the cortex were significantly more in p50-/- mice than that in wild type mice, and neuronal cells in the cortex, hippocampus and caudate nucleus-putamen decreased in p50-/- mice. Fewer myelinated axons of the optic nerve were found in p50-/- mice than in wild type mice at 6 months. In p50-/- mice, morphological examinations showed: 1) aging and degenerative changes in the cortex and hippocampus including increased lipofuscin granules in neural cytoplasm, 2) abnormal cap...Continue Reading

References

Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Jun 1, 1994·Molecular and Cellular Biology·C KaltschmidtP A Baeuerle
Jun 1, 1996·Brain Research. Molecular Brain Research·P J MebergA Routtenberg
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Jan 1, 1997·Free Radical Biology & Medicine·L FlohéL Packer
Feb 1, 1997·Aging : Clinical and Experimental Research·J T Venjatraman, G Fernandes
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·S HunotE C Hirsch
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Aug 8, 1998·Trends in Cell Biology·D J Van AntwerpD R Green
Mar 23, 1999·Nature Medicine·H Schneider, C Coutelle
Apr 14, 1999·Cell Death and Differentiation·A G Porter, R U Jänicke
Sep 15, 1999·Nature·J A Romashkova, S S Makarov
Jan 29, 2000·The Journal of Cell Biology·G MiddletonA M Davies
Apr 14, 2000·Brain Pathology·M P Mattson
Feb 13, 2001·The Journal of Clinical Investigation·M P Mattson, S Camandola
Feb 24, 2001·Journal of Molecular Neuroscience : MN·Z YuM P Mattson
Nov 22, 2001·Experimental Neurology·K R PennypackerA E Willing
Mar 5, 2002·Nature Immunology·Michael Karin, Anning Lin
Apr 9, 2002·Experimental Hematology·Xiaoxia Li, George R Stark
Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Udo Bartsch
Jan 30, 2003·Nature Neuroscience·Mark P Mattson
Sep 1, 1951·The Journal of Physiology·W A H RUSHTON
Feb 28, 2004·Brain, Behavior, and Immunity·Louise C Hawkley, John T Cacioppo
Aug 18, 2004·Behavioural Brain Research·Cheryl A Kassed, Miles Herkenham

❮ Previous
Next ❯

Citations

Oct 31, 2013·European Journal of Human Genetics : EJHG·Alexandra KretzRonny Haenold
Jun 30, 2010·PLoS Computational Biology·Andres KrieteGlenn Booker
Jul 25, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Lihong ShiXiuning Sun
Sep 19, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hwee-Luan Ang, Vinay Tergaonkar
Dec 21, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Michael J FlisterSophia Ran
Oct 22, 2010·Aging Cell·Visish SrinivasanS Michal Jazwinski
Apr 20, 2010·Brain, Behavior, and Immunity·Michael L LehmannMiles Herkenham
Sep 25, 2012·The American Journal of Pathology·Xinghui Sun, Mark W Feinberg
Jun 7, 2014·Frontiers in Molecular Neuroscience·Thomas Blank, Marco Prinz
Jul 13, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Stefka Mincheva-Tasheva, Rosa M Soler
Apr 30, 2011·Circulation Research·Joseph W GordonLorrie A Kirshenbaum
Jan 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Lorraine SundaySue P Duckles
Jul 16, 2015·American Journal of Physiology. Endocrinology and Metabolism·Yoshihiko MinegishiTakatoshi Murase
Apr 9, 2020·Frontiers in Immunology·Yifan ZhouWei Qiu
Feb 10, 2009·Clinical Science·Ee Tsin Wong, Vinay Tergaonkar
Feb 24, 2015·Oncotarget·Bakhtiar Yamini
Dec 18, 2020·Frontiers in Veterinary Science·Haley E RymutSandra L Rodriguez-Zas

❮ Previous
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