Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans

Oncotarget
Mehran RahimiFarhad Rezaee

Abstract

Despite numerous developed drugs based on glucose metabolism interventions for treatment of age-related diseases such as diabetes neuropathies (DNs), DNs are still increasing in patients with type 1 or type 2 diabetes (T1D, T2D). We aimed to identify novel candidates in adipose tissue (AT) and pancreas with T2D for targeting to develop new drugs for DNs therapy. AT-T2D displayed 15 (e.g. SYT4 up-regulated and VGF down-regulated) and pancreas-T2D showed 10 (e.g. BAG3 up-regulated, VAV3 and APOA1 down-regulated) highly differentially expressed genes with neuronal functions as compared to control tissues. ELISA was blindly performed to measure proteins of 5 most differentially expressed genes in 41 human subjects. SYT4 protein was upregulated, VAV3 and APOA1 were down-regulated, and BAG3 remained unchanged in 1- Obese and 2- Obese-T2D without insulin, VGF protein was higher in these two groups as well as in group 3- Obese-T2D receiving insulin than 4-lean subjects. Interaction networks analysis of these 5 genes showed several metabolic pathways (e.g. lipid metabolism and insulin signaling). Pancreas is a novel site for APOA1 synthesis. VGF is synthesized in AT and could be considered as good diagnostic, and even prognostic, marker...Continue Reading

References

Dec 1, 1966·Psychometrika·G Sabidussi
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G SchmitzR W Mahley
Oct 29, 1993·Biochemical and Biophysical Research Communications·K NakataH Hamaguchi
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·Q R LuP M Black
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T PurvesD R Tomlinson
Jan 10, 2003·Nucleic Acids Research·Christian von MeringBerend Snel
Feb 11, 2003·Journal of Lipid Research·Greg PankhurstRoland Stocker
May 22, 2003·Progress in Neurobiology·Hitoshi YasudaRyuichi Kikkawa
Nov 20, 2003·Cellular and Molecular Life Sciences : CMLS·A A F Sima
Aug 4, 2004·EMBO Reports·Vicki Brower
Aug 6, 2004·Endocrine Reviews·Andrea M VincentEva L Feldman
Jan 19, 2006·Proteomics·Farhad RezaeeJoost C M Meijers
Mar 1, 2006·Diabetes/metabolism Research and Reviews·Rodica Pop-BusuiMartin Stevens
Jan 18, 2007·World Journal of Gastroenterology : WJG·Maxim DobretsovJoseph R Stimers
Sep 8, 2007·Proteome Science·Johannes Hm LevelsJoost Cm Meijers
Mar 4, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiromu Sakurai
Jul 12, 2008·Pharmacology & Therapeutics·James L EdwardsEva L Feldman
Aug 19, 2008·Reviews in Endocrine & Metabolic Disorders·Claudia Figueroa-RomeroEva L Feldman
Aug 30, 2008·The Mount Sinai Journal of Medicine, New York·Michael P MorranMassimo Pietropaolo
Oct 18, 2008·Diabetes, Obesity & Metabolism·R ScharfmannG Guillemain
Feb 6, 2009·Cellular and Molecular Life Sciences : CMLS·K Toshinai, M Nakazato
May 8, 2009·Medical Hypotheses·Michael G Tal
Feb 17, 2010·Aging·Mikhail V Blagosklonny
Sep 3, 2010·Diabetes·Benjamin A Cooperberg, Philip E Cryer
Feb 15, 2011·Neuron·Qingchun Tong
Mar 27, 2012·Neurobiology of Disease·Subir K Roy ChowdhuryPaul Fernyhough
Sep 4, 2012·The Journal of Endocrinology·Samira FargaliStephen R Salton
Dec 20, 2012·Molecular & Cellular Proteomics : MCP·Kazuki SasakiNaoto Minamino
Mar 16, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ken T CoppietersMatthias G von Herrath
Mar 21, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Roberto Mallone, Bart O Roep
Mar 30, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Aaron W Michels
Aug 1, 2013·Nature Methods·Alberto CalderoneGianni Cesareni

❮ Previous
Next ❯

Citations

Sep 13, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Sa'ad Al-Lahham, Farhad Rezaee
Feb 6, 2017·Scientific Reports·Nuria Perretta-TejedorCarlos Martínez-Salgado
Jul 12, 2017·Journal of Cellular Physiology·Giuseppe DerosaMaria C Turco
Sep 29, 2020·Frontiers in Neuroscience·María Teresa Flores-DorantesRuth Gutiérrez-Aguilar
Aug 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Khaled BenchoulaWong Eng Hwa

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleotide exchange
ELISA
biopsies

Software Mentioned

Ingenuity Pathway Analysis
Beadstudio Expression
BioGRID
SPSS

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.