Age-related prevalence of complement-fixing antibody to Mycoplasma pneumoniae during an 8-year period.

Journal of Clinical Microbiology
A Pönkä, P Ukkonen

Abstract

We determined the age-related prevalence of complement-fixing antibody to Mycoplasma pneumoniae from the computerized laboratory results of our routine diagnostic department. The material consisted of about 58,000 sera from an 8-year period, 1971 to 1978. Among children less than 1 month old, the frequency of complement-fixing antibody of titers greater than or equal to 8 was low (23%), and no decrease representing loss of maternal antibody was seen thereafter. An unexpectedly early increase in the antibody prevalence up to 62% was seen by 6 months of age. The frequency of antibody was high among young children from the age of 4 months, in whom symptomatic infection due to M. pneumoniae is rare. The frequency of higher titers (greater than or equal to 32) and the geometric mean titer increased more slowly, coinciding with the known age distribution of symptomatic M. pneumoniae disease; the frequency of high titers and the geometric mean titer peaked at the age of 7 to 10 years. Two explanations for the high frequency of complement-fixing antibody to M. pneumoniae in young children are discussed. It may be due to an asymptomatic infection caused by M. pneumoniae or to a nonspecific stimulus by lipids of other organisms, plants, ...Continue Reading

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Citations

Aug 1, 1991·Epidemiology and Infection·K Lind, M W Bentzon
Aug 16, 2005·Journal of Korean Medical Science·Jinho YuYoung Yull Koh
Jan 10, 2006·Journal of Paediatrics and Child Health·N OthmanA Kesson
Jul 30, 2008·Expert Review of Anti-infective Therapy·Kyung-Yil Lee
Sep 13, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Mehmet BosnakKenan Haspolat
Apr 1, 1989·Epidemiology and Infection·M PuolakkainenP Saikku

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