Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia

Neuroscience Bulletin
Yin LinTao Li

Abstract

Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia. Meanwhile, progressive neurodegenerative processes have also been reported, leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of schizophrenia. However, a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain structures. To clarify this potential confounding factor, we measured the cortical thickness across the whole brain using high-resolution T1-weighted magnetic resonance imaging in 145 first-episode and treatment-naïve patients with schizophrenia and 147 healthy controls. The results showed that, in the patient group, the frontal, temporal, parietal, and cingulate gyri displayed a significant age-related reduction of cortical thickness. In the control group, age-related cortical thickness reduction was mostly located in the frontal, temporal, and cingulate gyri, albeit to a lesser extent. Importantly, relative to healthy controls, patients exhibited a significantly smaller age-related cortical thickness in the anterior cingulate, inferior temporal, and insular gyri in the right hemisphere. These results provide evidence ...Continue Reading

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Citations

Feb 6, 2020·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Eric A NelsonAdrienne C Lahti
Aug 20, 2020·Neuroscience Bulletin·Nianming ZuoTianzi Jiang
Jun 5, 2020·Neuroscience Bulletin·Wasana Ediri ArachchiMeng Liang
Aug 6, 2020·Frontiers in Psychiatry·Tsutomu TakahashiMichio Suzuki

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