Age-related reexpression of p75 in axotomized motoneurons

Neuroreport
Qiuju YuanWutian Wu

Abstract

p75 was immunohistochemically identified in spinal motoneurons in immature and adult rats after either distal peripheral axotomy or root avulsion. Few or no p75 positive motoneurons were observed after distal axotomy in animals at the age of postnatal day 1 and postnatal day 7, whereas the injury induced marked neuronal death. Motoneurons reexpressed p75 from the end of the second postnatal week to adulthood in response to distal axotomy, whereas most motoneurons survived after the injury. On the other hand, root avulsion in animals of all ages did not cause significant p75 expression in avulsed motoneurons where most motoneurons died ultimately. The potential role of such reexpression in motoneuron protection is discussed.

References

Apr 1, 1995·Current Opinion in Cell Biology·M Barbacid
Jun 1, 1996·Neuroscience Research·C Ide
Mar 8, 2000·Progress in Neurobiology·G L Barrett
Oct 6, 2000·Journal of Neurobiology·X P Zhang, R T Ambron
Jun 28, 2002·Neuron·Jin QiuMarie T Filbin
Jul 24, 2003·Developmental Neuroscience·Qiuju YuanWutian Wu

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Citations

Oct 27, 2009·Journal of Brachial Plexus and Peripheral Nerve Injury·Qiuju YuanWutian Wu
Nov 26, 2009·Nitric Oxide : Biology and Chemistry·Jiachuan WangLi-Hua Zhou

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