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Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression

Molecular Psychiatry

Aug 1, 2015

Maria H MilekicJay A Gingrich

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Abstract

Advanced paternal age (APA) has been shown to be a significant risk factor in the offspring for neurodevelopmental psychiatric disorders, such as schizophrenia and autism spectrum disorders. During aging, de novo mutations accumulate in the male germline and are frequently transmitted t...read more

Mentioned in this Paper

Gene Expression
Age Factors
Psychiatry Specialty
Transcriptional Regulation
Schizophrenia
Genes, Developmental
Fetishism (Psychiatric)
Y-Chromosome-Bearing Sperm
Metazoa
Brain
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122
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  • References49
  • Citations21
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Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression

Molecular Psychiatry

Aug 1, 2015

Maria H MilekicJay A Gingrich

PMID: 25092244

DOI: 10.1038/mp.2014.84

Abstract

Advanced paternal age (APA) has been shown to be a significant risk factor in the offspring for neurodevelopmental psychiatric disorders, such as schizophrenia and autism spectrum disorders. During aging, de novo mutations accumulate in the male germline and are frequently transmitted t...read more

Mentioned in this Paper

Gene Expression
Age Factors
Psychiatry Specialty
Transcriptional Regulation
Schizophrenia
8
1
1
122

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References49
  • Citations21
123

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