Age-related structural and functional changes of low back muscles

Experimental Gerontology
Patrick HiepeJürgen R Reichenbach

Abstract

During aging declining maximum force capacity with more or less unchanged fatigability is observed with the underlying mechanisms still not fully understood. Therefore, we compared morphology and function of skeletal muscles between different age groups. Changes in high-energy phosphate turnover (PCr, Pi and pH) and muscle functional MRI (mfMRI) parameters, including proton transverse relaxation time (T2), diffusion (D) and vascular volume fraction (f), were investigated in moderately exercised low back muscles of young and late-middle-aged healthy subjects with (31)P-MR spectroscopy, T2- and diffusion-weighted MRI at 3T. In addition, T1-weighted MRI data were acquired to determine muscle cross-sectional areas (CSA) and to assess fat infiltration into muscle tissue. Except for pH, both age groups showed similar load-induced MR changes and rates of perceived exertion (RPE), which indicates comparable behavior of muscle activation at moderate loads. Changes of mfMRI parameters were significantly associated with RPE in both cohorts. Age-related differences were observed, with lower pH and higher Pi/ATP ratios as well as lower D and f values in the late-middle-aged subjects. These findings are ascribed to age-related changes of fib...Continue Reading

References

Jan 1, 1990·Scandinavian Journal of Work, Environment & Health·G Borg
Feb 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D J TaylorG K Radda
Jan 1, 1995·Magnetic Resonance Imaging·D Morvan, A Leroy-Willig
Jan 4, 1998·Journal of Magnetic Resonance·L Vanhamme Van Huffel S
Sep 17, 2005·Journal of Applied Physiology·Nicholas A RyanTimothy P Gavin
Jan 13, 2006·Experimental Physiology·Gregory F MartelMarc A Rogers
May 13, 2006·Journal of Applied Physiology·Marko T KorhonenHarri Suominen
Nov 2, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Bret H GoodpasterAnne B Newman
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Chris Boesch
Mar 29, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bruce M DamonJane A Kent-Braun
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bruce M DamonDrew A Lansdown
Oct 26, 2007·Journal of Biomechanics·Christoph AndersHans-Christoph Scholle
May 9, 2008·European Radiology·J F DeuxA Rahmouni
Jan 13, 2009·Biological Reviews of the Cambridge Philosophical Society·Juliet A Usher-SmithJames A Fraser
Apr 21, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D Walter WrayRussell S Richardson
Sep 15, 2009·Journal of Manipulative and Physiological Therapeutics·Annick ChampagneDanik Lafond
Nov 6, 2009·International Journal of Biomedical Imaging·José V ManjónMontserrat Robles
Apr 8, 2010·Journal of Magnetic Resonance Imaging : JMRI·Dimitrios C KarampinosJohn G Georgiadis
Jul 2, 2011·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Noriyuki TawaraAkiyoshi Itoh
Apr 5, 2013·NMR in Biomedicine·Michael ScheelGerd Diederichs
Aug 8, 2014·Journal of Applied Biomechanics·Eduard KurzHans-Christoph Scholle

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