PMID: 11911504Mar 26, 2002Paper

Age-related sympathetic ganglionic neuropathology: human pathology and animal models

Autonomic Neuroscience : Basic & Clinical
Robert E Schmidt

Abstract

Systematic studies of the autonomic nervous system of human subjects and development of well-defined animal models have begun to substantially improve our understanding of the pathogenesis of autonomic dysfunction in aging and may eventually provide strategies for intervention. Neuropathological studies of the sympathetic ganglia of aged human subjects and rodent models have demonstrated that neuroaxonal dystrophy involving intraganglionic terminal axons and synapses is a robust, unequivocal and consistent neuropathological finding in the aged sympathetic nervous system of man and animals. Quantitative studies have demonstrated that markedly swollen argyrophilic dystrophic axon terminals develop in the prevertebral superior mesenteric (SMG) and coeliac, but to a much lesser degree in the superior cervical ganglia (SCG) as a function of age, sex (males more than females) and diabetes. Dystrophic axons were immunoreactive for neuropeptide Y, tyrosine hydroxylase, dopamine-beta-hydroxylase, trkA and p75NTR, an immunophenotype consistent with their origin from postganglionic sympathetic neurons, and contained large numbers of highly phosphorylated neurofilaments or tubulovesicular elements. The sympathetic ganglia of aged rodents a...Continue Reading

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Citations

Jul 25, 2003·Autonomic Neuroscience : Basic & Clinical·Robert J PhillipsTerry L Powley
Nov 26, 2008·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Vladimir ZivkovićMiljana Pavlović
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Jul 27, 2007·Clinical and Experimental Hypertension : CHE·Karim Alkadhi, Karem Alzoubi
Nov 20, 2008·Journal of Neuropathology and Experimental Neurology·Robert E SchmidtKaren G Green
May 25, 2010·Experimental Eye Research·Youde JiangJena J Steinle
Dec 30, 2008·Experimental Neurology·Robert E SchmidtDongyan Feng
Jun 24, 2006·Neurobiology of Aging·Robert J PhillipsTerry L Powley
Jul 7, 2007·The Journal of Comparative Neurology·Jing AiZixi Cheng
Nov 29, 2014·The European Journal of Neuroscience·Andrew R ChandnaVerónica A Campanucci
Oct 3, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Sarah M O'DonovanCora O'Neill
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paul R Wade

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