PMID: 8582786Sep 1, 1995Paper

Age-related thymus involution: zinc reverses in vitro the thymulin secretion defect

International Journal of Immunopharmacology
E Mocchegiani, N Fabris

Abstract

The inevitability of thymic involution in aging has been opened to question by two recent findings. First, it has been demonstrated that the synthesis and/or secretion of one thymic factor, zinc-thymulin (Zn-FTS), is still present, although reduced, in humans over 90 yr of age and in mice over 24 months of age. The major defect resides in the zinc saturation of thymulin, rather than in the synthesis and secretion rate of the polypeptide by the thymus. Zinc pool is in fact reduced in old age. Thymic explants from old mice in vitro for a short period (6 h) produce nearly the same amount of thymulin as young thymuses, but the zinc-bound form is nearly absent. Zinc addition to the cultures fully recovers the defect. These findings clearly suggest that thymic involution is not an intrinsic and irreversible phenomenon, but is largely due to microenvironmental factors, among which zinc is crucial.

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Citations

Sep 28, 2005·Archives of Toxicology·M StefanidouC Spiliopoulou
Nov 11, 2011·Archives of Toxicology·Christos T ChasapisMaria E Stefanidou
Sep 12, 2006·Biogerontology·Wayne A MitchellRichard Aspinall
Apr 26, 2003·Mechanisms of Ageing and Development·Robertina GiacconiEugenio Mocchegiani
Jan 12, 1999·Mechanisms of Ageing and Development·E MocchegianiR Giacconi
Jul 16, 1999·Mechanisms of Ageing and Development·B Chakravarti, G N Abraham
Jun 1, 2000·Experimental Gerontology·W PierpaoliS Arrighi
Jul 1, 1997·Experimental Gerontology·N FabrisM Provinciali
Jan 28, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A SbarbatiF Osculati
Jul 16, 2003·International Immunopharmacology·K MasekJ W Hadden
May 25, 1999·Periodontology 2000·W P McArthur
Dec 16, 1998·Molecular Pathology : MP·S J NaylerK Cooper
Dec 16, 1998·Molecular Pathology : MP·P BroussetG Delsol
Sep 6, 2000·Clinical and Experimental Immunology·R ConsoliniM Milani
Aug 10, 2010·Transplant Immunology·Atsushi HirakataKazuhiko Yamada
Mar 1, 1997·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·B M Lesourd, L Mazari
Jul 14, 2021·Annual Review of Nutrition·Inga WesselsLothar Rink

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