Age-related variation in seminiferous tubules in men. A stereologic evaluation

Journal of Andrology
Larry JohnsonW B Neaves

Abstract

Tubular boundary tissue and seminiferous epithelia were evaluated stereologically in testes from 28 men aged 20 to 48 years and 28 men aged 50 to 90 years. Testes obtained at autopsy within 15 hours of death were perfused with glutaraldehyde, embedded in Epon (Ladd Research Industries, Inc., Burlington, VT), sectioned at 0.5 micron, and stained with toluidine blue. Volume densities (percentage of the testicular parenchyma) of various parameters determined by point counting and diameter measurements were used to calculate total volumes, length of tubules, and number of cells. Electron microscopy was used to determine the volume density of myoid cells in the boundary tissue. Significant (P less than 0.01) age-related reductions occurred in paired testicular weights, paired parenchymal weights, total volume of seminiferous tubules and of seminiferous epithelium, and length of tubules. The volume density and thickness of boundary tissue increased (P less than 0.01) with age. The volume of boundary tissue per man and the volume density of myoid cells in the boundary tissue did not vary with age. Although the number of myoid cells per man tended to be lower in the older group, the number of myoid cells per cross section of seminifero...Continue Reading

References

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Citations

Oct 1, 1991·Journal of Electron Microscopy Technique·R PaniaguaB Fraile
Dec 1, 1995·Microscopy Research and Technique·L Johnson
Jan 25, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Jens EhmckeStefan Schlatt
Apr 25, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joana SantiagoMargarida Fardilha
Dec 1, 2011·Nuclear Medicine and Molecular Imaging·Seung Hwan MoonMyung Chul Lee
Aug 31, 2018·Andrologia·Anne-Laure BarbotinValerie Mitchell
May 8, 2019·Veterinary Pathology·Sophie E MerzAchim D Gruber
Jun 21, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna HentrichLutz Konrad
Nov 1, 1986·Journal of Andrology·L Johnson
Sep 19, 2007·Annals of Nuclear Medicine·Kazuhiro KitajimaKazuro Sugimura
Apr 12, 2012·Biology of Reproduction·Gerard A TarulliSarah J Meachem
Aug 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael CurleyLee B Smith
Mar 11, 2018·Journal of Assisted Reproduction and Genetics·Alexander N Yatsenko, Paul J Turek
Oct 24, 2020·Human Reproduction·Valentina MularoniCarla Boitani
Dec 9, 2008·Molecular and Cellular Endocrinology·Antti Perheentupa, Ilpo Huhtaniemi

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