Age-related variations in jejunum and distal colon contractile response to thyrotropin-releasing hormone in vitro

Biology of the Neonate
M Heitkemper, E Bond

Abstract

The effects of thyrotropin-releasing hormone (TRH) on the contractile activity of the proximal jejunum and distal colon of 3-, 7-, 14-, 21-, 28-, 50-day-old and adult male Sprague-Dawley rats were examined. Longitudinal segments were mounted in force displacement transducers and bathed in oxygenated, buffered Krebs' solution. In the proximal jejunum TRH 10(-6) M produced a tetrodotoxin (TTX)-sensitive tension increase in 3- to 14-day-old rats and a TTX-resistant biphasic response in older rats. TRH 10(-6) M produced a transient tension in the distal colon of rats less than or equal to 21 days old. Incubation with TRH 10(-6) M for 30 min increased responsiveness to acetylcholine 10(-7) M in approximately 50% of tissues studied. Direct and indirect effects of TRH are developmentally determined.

Citations

Feb 4, 1990·Regulatory Peptides·E Bond, M Heitkemper

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