PMID: 3764313Jan 1, 1986Paper

Age-related variations in renal structure and function in Sprague-Dawley rats

Toxicologic Pathology
R A Owen, R Heywood

Abstract

Data from 500 male and 500 female Sprague-Dawley rats used as controls in studies performed at Huntingdon Research Centre to assess the safety of drugs were sampled at 17, 30, 56, 82, or 108 weeks of age. Plasma urea nitrogen levels remained constant, except in aged males. Aging caused increased proteinuria and decreased urinary concentrating ability, in addition to increased size, weight, and degree of cortical scarring of kidneys. Chronic progressive nephropathy, first seen histopathologically at 30 weeks of age, accounted for these changes and ultimately affected 81% of male and 44% of female rats. One-fifth of two-year-old male rats had diffuse parenchymal damage and a small number also had secondary hyperparathyroidism. Other notable changes included basophilic (often colloid-filled) cortical tubules, mononuclear cell infiltrations, parenchymal and pelvic mineralization, urothelial hyperplasia, and pyelonephritis. Miscellaneous low incidence findings included one lipomatous tumour and generalized lymphosarcoma.

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Citations

Dec 3, 2008·International Urology and Nephrology·R Podkowka-SieczkaD G Oreopoulos
Mar 1, 1992·Mechanisms of Ageing and Development·B CormanG Geelen
Nov 3, 2012·Journal of Toxicology and Environmental Health. Part a·Dale J Marino
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·L Castelletto, R G Goya
Nov 12, 2010·Expert Opinion on Drug Metabolism & Toxicology·Andrea TrevisanFederica Chiara
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Jun 1, 1992·Kidney International·L D TruongD Gillum
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Jul 31, 2007·Ageing Research Reviews·M Shawkat Razzaque
Sep 11, 2009·Journal of Applied Toxicology : JAT·Edoardo ZanettiAndrea Trevisan
Jun 9, 2016·Acta Cirúrgica Brasileira·Eduardo Felippe MelchiorettoRogério de Fraga
Jul 17, 1998·Toxicology and Industrial Health·R PoonV Valli
Jan 4, 2007·The Journal of Pathology·J E Martin, M T Sheaff
Sep 1, 2005·International Urology and Nephrology·Fred G Silva
Mar 3, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ruud BuetersKendall S Frazier
Aug 6, 2013·Journal of Toxicologic Pathology·Yuichi KuroiwaShuzo Okazaki
Dec 18, 2020·Acta Cirúrgica Brasileira·Eduardo Felippe MelchiorettoRogerio de Fraga
May 8, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shakil Ahmed SaghirMichael A Dorato

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