Feb 28, 2020

Age-related visual dynamics in HIV-infected adults with cognitive impairment

Neurology. Neuroimmunology and Neuroinflammation
Boman R GroffTony W Wilson

Abstract

To investigate whether aging differentially affects neural activity serving visuospatial processing in a large functional neuroimaging study of HIV-infected participants and to determine whether such aging effects are attributable to differences in the duration of HIV infection. A total of 170 participants, including 93 uninfected controls and 77 HIV-infected participants, underwent neuropsychological assessment followed by neuroimaging with magnetoencephalography (MEG). Time-frequency analysis of the MEG data followed by advanced image reconstruction of neural oscillatory activity and whole-brain statistical analyses were used to examine interactions between age, HIV infection, and cognitive status. Post hoc testing for a mediation effect of HIV infection duration on the relationship between age and neural activity was performed using a quasi-Bayesian approximation for significance testing. Cognitively impaired HIV-infected participants were distinguished from unimpaired HIV-infected and control participants by their unique association between age and gamma oscillations in the parieto-occipital cortex. This relationship between age and gamma was fully mediated by the duration of HIV infection in cognitively impaired participan...Continue Reading

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Mentioned in this Paper

Research Activities
Brain Activity
Magnetoencephalography
HIV Infections
Analysis
Brain Waves
Peer
Participant
Visuospatial Agnosia
Neuroimaging

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