Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients

Cell Death & Disease
R. AngioniBarbara Molon

Abstract

A global effort is currently undertaken to restrain the COVID-19 pandemic. Host immunity has come out as a determinant for COVID-19 clinical outcomes, and several studies investigated the immune profiling of SARS-CoV-2 infected people to properly direct the clinical management of the disease. Thus, lymphopenia, T-cell exhaustion, and the increased levels of inflammatory mediators have been described in COVID-19 patients, in particular in severe cases1. Age represents a key factor in COVID-19 morbidity and mortality2. Understanding age-associated immune signatures of patients are therefore important to identify preventive and therapeutic strategies. In this study, we investigated the immune profile of COVID-19 hospitalized patients identifying a distinctive age-dependent immune signature associated with disease severity. Indeed, defined circulating factors - CXCL8, IL-10, IL-15, IL-27, and TNF-α - positively correlate with older age, longer hospitalization, and a more severe form of the disease and may thus represent the leading signature in critical COVID-19 patients.

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Citations

Jan 7, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anthony V IncognitoW Glen Pyle
Mar 21, 2021·Cell·Joachim L Schultze, Anna C Aschenbrenner
Apr 4, 2021·International Journal of Molecular Sciences·Fanny PojeroAnna Aiello

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Methods Mentioned

BETA
Assay
ESR
FACS
flow cytometry
density-gradient sedimentation
ELISA

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