Age, sex and the association between skin test responses and IgE titres with asthma

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Hasan Raza MohammadAdnan Custovic

Abstract

Skin prick tests (SPTs) and allergen-specific serum IgE (sIgE) measurements are the main diagnostic tools for confirming atopic sensitization. Results are usually reported as 'positive' or 'negative', using the same arbitrary cut-offs (SPT>3 mm, sIgE>0.35 kUA /l) across different ages and sexes. We investigated the influence of age and sex on the interpretation of allergy test in the context of childhood asthma. In a population-based birth cohort (n = 1051), we ascertained the information on asthma/wheeze (validated questionnaires) and performed SPTs and sIgE measurement to inhalant allergens (dust mite, cat, dog) at follow-ups between ages three and 11 years. We investigated the association between quantitative sensitization (sum of SPT mean wheal diameters [MWD] and sIgE titres to the three allergens) and current wheeze and asthma across ages and sexes. We observed a significant association between the SPT MWD and sIgE titres and wheeze/asthma at most ages and for both sexes. However, the strength of this association was age- and sex-dependent. For SPTs, the strength of the association between MWD and asthma increased with increasing age; we observed the opposite pattern for sIgE titre. For any given SPT MWD/sIgE titre, boys ...Continue Reading

References

Aug 1, 1992·Allergy·N R Niemeijer, J G de Monchy
Jul 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M R SearsP A Silva
Nov 1, 1987·The Journal of Allergy and Clinical Immunology·W Skassa-BrociekJ Bousquet
Nov 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D JarvisP Burney
Mar 1, 1997·The Journal of Allergy and Clinical Immunology·P BurneyE Lai
Sep 7, 2001·The Journal of Allergy and Clinical Immunology·E O Addo-YoboA Woodcock
Apr 12, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Adnan CustovicUNKNOWN NAC Manchester Asthma and Allergy Study Group
May 8, 2004·The Journal of Allergy and Clinical Immunology·Hugh A Sampson
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Mahdi Sayed Hassan Al-MousawiAdnan Custovic
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Graham Roberts, Gideon Lack
Oct 8, 2005·The Journal of Allergy and Clinical Immunology·Angela SimpsonAdnan Custovic
May 27, 2008·The Journal of Allergy and Clinical Immunology·Jennifer M MaloneyHugh A Sampson
Nov 5, 2011·Allergy·J BousquetUNKNOWN Allergic Rhinitis and its Impact on Asthma
Dec 28, 2011·Pediatrics·Scott H SichererUNKNOWN American Academy of Pediatrics Section On Allergy And Immunology
Sep 7, 2012·PloS One·Karin C Lødrup CarlsenUNKNOWN GALEN WP 1.5 ‘Birth Cohorts’ working group
Feb 7, 2013·Current Opinion in Allergy and Clinical Immunology·Adnan CustovicAngela Simpson
Oct 18, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Mattia C F ProsperiAdnan Custovic
Jan 15, 2014·Allergy·A CustovicN G Papadopoulos
Mar 13, 2014·American Journal of Respiratory and Critical Care Medicine·Danielle C M BelgraveAdnan Custovic
May 4, 2015·The Journal of Allergy and Clinical Immunology·Angela SimpsonAdnan Custovic
May 13, 2015·The Journal of Allergy and Clinical Immunology·Adnan CustovicMattia C F Prosperi
May 27, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Hannah GoughUNKNOWN MAS study group

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Citations

Oct 11, 2016·Allergologia et immunopathologia·M A ToscaG Ciprandi
Mar 8, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Paraskevi XepapadakiNikolaos G Papadopoulos
May 17, 2019·Human Molecular Genetics·Yadu GautamTesfaye B Mersha
Feb 2, 2018·Current Opinion in Allergy and Clinical Immunology·Ceyda Oksel, Adnan Custovic
Jan 9, 2019·Frontiers in Immunology·Ruchi Shah, Dawn C Newcomb
Apr 16, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jonatan LefflerDeborah H Strickland
Aug 30, 2019·Frontiers in Pediatrics·Jose A Castro-RodriguezFernando D Martinez
Oct 6, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Elisabeth Soegaard ChristiansenSusanne Halken
Sep 15, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Maureen SabitJohn Donnie Ramos
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Baoming WangBrian G Oliver
Jun 9, 2018·International Journal of Molecular Sciences·Jonatan LefflerDeborah H Strickland
Jul 6, 2019·Frontiers in Pediatrics·Hans-Joachim SonntagAdnan Custovic
Jul 9, 2021·BMJ Open·Shashanka Indeevara Rajapakse Rajapakse MudiyanselageSuneth Agampodi

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