PMID: 11918548Mar 29, 2002Paper

Age, sex and vitamin status affect plasma level of homocysteine, but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinese

British Journal of Haematology
Jen-Shiou LinMei-Hua Hung

Abstract

The biological effects of age, sex and vitamin status on plasma total homocysteine (tHcy), and association of hyperhomocysteinaemia with venous thromboembolism in Taiwanese Chinese individuals, were investigated. Eighty patients (16-85 years) with venous thrombophilia and 123 healthy subjects (15-85 years) without history of vascular thrombosis were studied for plasma levels of tHcy, folate and vitamin B12. A multivariate analysis in healthy subjects revealed that plasma tHcy levels tended to increase with age (P < 0.001) and with decreasing plasma levels of folate (P=0.001) or vitamin B12 (P < 0.029); men tended to have higher plasma tHcy levels than women (P=0.006). Thrombotic risk assessment in a case-control study demonstrated that neither plasma level of tHcy [odds ratio (OR), 1.07; 95% confidence interval (CI), 0.96-1.18; P=0.210] nor hyperhomocysteinaemia (OR, 1.65; 95% CI, 0.50-5.49; P=0.415) was significantly associated with venous thrombophilia. The relationship between hyperhomocysteinaemia and recurrence of episode remained insignificant (P=0.560). We conclude that age, sex and vitamin status affect plasma tHcy but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese C...Continue Reading

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Citations

Jun 11, 2004·Annual Review of Nutrition·Sally P Stabler, Robert H Allen
Jan 27, 2005·Journal of Thrombosis and Haemostasis : JTH·M Den HeijerR Clarke
May 12, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K A L DarvallA W Bradbury
Jul 17, 2013·Journal of the Neurological Sciences·Mahmoud AllamEngy El-Sawy
Jul 4, 2015·Thrombosis Research·Alexander CohenRaymond Wong
Sep 27, 2008·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Véronique DucrosJean-Luc Bosson
Apr 9, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Alfredo CopertaroLory Santarelli
Mar 9, 2012·Gynecologic and Obstetric Investigation·Wing-Hung TamChi-Yin Li
Jul 28, 2020·Journal of Clinical Medicine·Julia HinkelSarah C Grünert

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