Age, smoking and overweight contribute to the development of intestinal metaplasia of the cardia.

World Journal of Gastroenterology : WJG
Christian FelleyJean Louis Frossard

Abstract

To assess the role of Helicobacter pylori (H. pylori), gastroesophageal reflux disease (GERD), age, smoking and body weight on the development of intestinal metaplasia of the gastric cardia (IMC). Two hundred and seventeen patients scheduled for esophagogastroduodenoscopy were enrolled in this study. Endoscopic biopsies from the esophagus, gastroesophageal junction and stomach were evaluated for inflammation, the presence of H. pylori and intestinal metaplasia. The correlation of these factors with the presence of IMC was assessed using logistic regression. IMC was observed in 42% of the patients. Patient age, smoking habit and body mass index (BMI) were found as potential contributors to IMC. The risk of developing IMC can be predicted in theory by combining these factors according to the following formula: Risk of IMC = a + s - 2B where a = 2,…6 decade of age, s = 0 for non-smokers or ex-smokers, 1 for < 10 cigarettes/d, 2 for > 10 cigarettes/d and B = 0 for BMI < 25 kg/m² (BMI < 27 kg/m² in females), 1 for BMI > 25 kg/m² (BMI > 27 kg/m² in females). Among potential factors associated with IMC, H. pylori had borderline significance (P = 0.07), while GERD showed no significance. Age, smoking and BMI are potential factors assoc...Continue Reading

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Citations

Jun 22, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Arvid SchigtBart van Wagensveld
Oct 1, 2014·Annals of the New York Academy of Sciences·Sahar Al-HaddadVincenzo Villanacci
Dec 12, 2012·The Journal of Thoracic and Cardiovascular Surgery·Robert J KorstMitchell Rubinoff
Nov 11, 2016·Journal of Cancer Research and Clinical Oncology·Jian-Xia JiangShun-Fu Xu
Aug 24, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Nari KimSujung Park
Feb 1, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kyungeun KimSeungho Ryu

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