Age-specific association between blood pressure and vascular and non-vascular chronic diseases in 0·5 million adults in China: a prospective cohort study

The Lancet Global Health
Ben LaceyChina Kadoorie Biobank Collaborative Group

Abstract

The age-specific association between blood pressure and vascular disease has been studied mostly in high-income countries, and before the widespread use of brain imaging for diagnosis of the main stroke types (ischaemic stroke and intracerebral haemorrhage). We aimed to investigate this relationship among adults in China. 512 891 adults (59% women) aged 30-79 years were recruited into a prospective study from ten areas of China between June 25, 2004, and July 15, 2008. Participants attended assessment centres where they were interviewed about demographic and lifestyle characteristics, and their blood pressure, height, and weight were measured. Incident disease was identified through linkage to local mortality records, chronic disease registries, and claims to the national health insurance system. We used Cox regression analysis to produce adjusted hazard ratios (HRs) relating systolic blood pressure to disease incidence. HRs were corrected for regression dilution to estimate associations with long-term average (usual) systolic blood pressure. During a median follow-up of 9 years (IQR 8-10), there were 88 105 incident vascular and non-vascular chronic disease events (about 90% of strokes events were diagnosed using brain imaging...Continue Reading

Citations

Sep 20, 2018·Journal of Epidemiology and Community Health·Denes Stefler, Leonardo Roever
Aug 6, 2018·Journal of Epidemiology and Community Health·Jian-Bing WangKun Chen
Nov 12, 2019·The International Journal of Health Planning and Management·Xiaoyan ZhangShiyu Yang
Oct 22, 2019·Hypertension·Yan LiUNKNOWN International Database on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome Investigators
Jun 23, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Aki YazawaIchiro Kawachi
Jul 17, 2020·Journal of the American Heart Association·Eric Yuk Fai WanCindy Lo Kuen Lam
Sep 19, 2018·Journal of Nephrology·Nicolás Roberto RoblesGuido Grassi
Dec 26, 2018·Stroke; a Journal of Cerebral Circulation·Iain John McGurganUNKNOWN China Kadoorie Biobank Consortium
Mar 30, 2020·Scientific Reports·Mohd A KarimUNKNOWN China Kadoorie Biobank Collaborative Group
Oct 28, 2020·Reviews in Endocrine & Metabolic Disorders·Maleesa M PathiranaPrabha H Andraweera
Mar 25, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Suebsarn Ruksakulpiwat
May 11, 2021·Journal of Hypertension·UNKNOWN The China PEACE Collaborative Group
Jun 1, 2021·Journal of Alzheimer's Disease : JAD·Xiaoyan SunRalph L Sacco
May 25, 2021·Chest·Yuxia WeiUNKNOWN China Kadoorie Biobank Collaborative Group
Jul 31, 2021·The Lancet Regional Health. Western Pacific·Fiona BraggUNKNOWN China Kadoorie Biobank (CKB) collaborative group (members listed in Supplementary appendix)
Jul 31, 2021·PloS One·Jie GuoUNKNOWN China Kadoorie Biobank Collaborative Group

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