Age-specific changes in the female-male mortality ratio related to the pattern of vaccinations: an observational study from rural Gambia

Vaccine
Peter AabyGijs Walraven

Abstract

According to studies from Guinea-Bissau and Senegal, live vaccines may reduce the female-male mortality ratio (MR) whereas inactivated vaccines increase this ratio. We used data from The Gambia to examine whether similar tendencies could be found in a different setting. Forty villages in the Farafenni area in rural Gambia. A population of 17,000 was followed with demographic surveillance between 1998 and 2002; 537 children less than 5 years of age died in this period. We used two vaccination surveys and community mortality data to examine, first, the female-male mortality ratio (MR) in the age groups in which DTP and MV are recommended and have a high coverage. Second, using vaccination cards seen post-mortem, we examined the distribution of live or inactivated vaccines as last vaccination in different age groups. Third, we examined the effect of DTP and MV administered simultaneously. The female-male MR in different age groups and for different vaccines. Vaccination coverage was high for BCG, third dose of DTP (DTP3) and MV, reaching a level of 80-90% within a few months of the recommended age of vaccination. First, the female-male MR was 0.93 (0.63-1.38) in the first 2 months of life when children had received no vaccination ...Continue Reading

Citations

Jul 25, 2007·International Journal of Epidemiology·Grace J ChanRobert E Black
Feb 16, 2008·International Journal of Epidemiology·Peter AabyHenrik Ravn
Jun 4, 2010·Expert Review of Vaccines·Katie L FlanaganMagdalena Plebanski
Apr 16, 2009·Vaccine·Peter AabyChristine S Benn
Jul 1, 2008·The Journal of Pediatrics·May-Lill GarlyIda Maria Lisse
Jan 9, 2007·Tropical Medicine & International Health : TM & IH·Peter AabyHenrik Jensen
Jan 9, 2007·Tropical Medicine & International Health : TM & IH·Henrik JensenPeter Aaby
Jul 30, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Najaaraq LundChristine Stabell Benn
Aug 21, 2013·Immunological Reviews·Laura F Su, Mark M Davis
Oct 20, 2006·Vaccine·Christine Stabell BennPeter Aaby
Jan 13, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Peter AabyJean-François Trape
Jun 30, 2016·Seminars in Immunology·Kristoffer Jarlov JensenReinout van Crevel
Jul 21, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fatou Noho-KontehKatie L Flanagan
Aug 18, 2018·Future Microbiology·Egle ButkeviciuteSteven G Smith
Aug 29, 2018·Journal of Leukocyte Biology·L C J de BreeMihai G Netea
Mar 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clara Clipet-JensenK Zaman
Jun 24, 2020·Human Vaccines & Immunotherapeutics·Syed Manzoor Ahmed HanifiAbbas Bhuiya
Jul 22, 2020·The Journal of Clinical Investigation·Valerie Acm KoekenMihai G Netea
Apr 17, 2020·Frontiers in Immunology·Kathrin BalzChrysanthi Skevaki
Jun 2, 2021·The Journal of Clinical Investigation·Alok K SinghWilliam R Bishai

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