Age specific differences in efficacy and safety for the CYD-tetravalent dengue vaccine

Expert Review of Vaccines
Annelies Wilder-Smith, Eduardo Massad

Abstract

CYD-TDV is the first dengue vaccine to have completed Phase 3 efficacy trials. Efficacy was consistently higher in those aged 9 and above for all variables studied: efficacy against virologically confirmed dengue of any severity and serotype, serotype specific efficacy, efficacy dependent on baseline seropositivity, efficacy against hospitalizations and efficacy against severe disease. Because of the higher efficacy and the absence of a safety signal, the age group with the best benefit of the use of CYD-TDV is individuals aged 9 and above - the age group for which licensure is now being sought.

References

Jun 7, 2002·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·María G GuzmánScott B Halstead
Jan 5, 2014·PLoS Neglected Tropical Diseases·Maria Glória TeixeiraGraham Joint
Jul 16, 2014·Lancet·Annelies Wilder-Smith
Nov 5, 2014·The New England Journal of Medicine·Luis VillarUNKNOWN CYD15 Study Group
Nov 7, 2014·PLoS Neglected Tropical Diseases·Kriengsak LimkittikulMaïna L'Azou
Dec 3, 2014·Vaccine·Thomas P MonathUNKNOWN Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG)
Jul 28, 2015·The New England Journal of Medicine·Sri Rezeki HadinegoroUNKNOWN CYD-TDV Dengue Vaccine Working Group
Nov 7, 2015·Science·Annelies Wilder-Smith, Duane J Gubler

❮ Previous
Next ❯

Citations

Feb 18, 2016·Expert Review of Vaccines·Annelies Wilder-Smith, In-Kyu Yoon
Feb 15, 2016·The Lancet Infectious Diseases·Annelies Wilder-Smith, Peter Byass
Jun 1, 2016·Pathogens and Global Health·Valérie R LouisHasitha A Tissera
Aug 9, 2016·The Journal of Infectious Diseases·Annelies Wilder-SmithTerry Nolan
Dec 3, 2016·The Journal of General Virology·Yie Hou LeeAnnelies Wilder-Smith
May 3, 2018·Journal of Medical Virology·Polly LeePaul Ks Chan
May 27, 2020·Expert Review of Vaccines·Usa Thisyakorn, Terapong Tantawichien
Apr 27, 2017·Asian Pacific Journal of Tropical Medicine·Ee Leen Pang, Hwei-San Loh
Jun 10, 2017·Infectious Diseases of Poverty·Leah MathiasEliningaya J Kweka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bulletin of the World Health Organization
J Clemens
The New England Journal of Medicine
Luis VillarCYD15 Study Group
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Sergio Isaac De La Cruz HernándezRosa María Del Angel
© 2022 Meta ULC. All rights reserved