Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.

International Journal of Cancer. Journal International Du Cancer
Quinn T OstromJill S Barnholtz-Sloan

Abstract

Glioblastoma (GBM) is the most common malignant brain tumor in the United States. Incidence of GBM increases with age, and younger age-at-diagnosis is significantly associated with improved prognosis. While the relationship between candidate GBM risk SNPs and age-at-diagnosis has been explored, genome-wide association studies (GWAS) have not previously been stratified by age. Potential age-specific genetic effects were assessed in autosomal SNPs for GBM patients using data from four previous GWAS. Using age distribution tertiles (18-53, 54-64, 65+) datasets were analyzed using age-stratified logistic regression to generate p values, odds ratios (OR), and 95% confidence intervals (95%CI), and then combined using meta-analysis. There were 4,512 total GBM cases, and 10,582 controls used for analysis. Significant associations were detected at two previously identified SNPs in 7p11.2 (rs723527 [p54-63 = 1.50x10-9 , OR54-63 = 1.28, 95%CI54-63 = 1.18-1.39; p64+ = 2.14x10-11 , OR64+ = 1.32, 95%CI64+ = 1.21-1.43] and rs11979158 [p54-63 = 6.13x10-8 , OR54-63 = 1.35, 95%CI54-63 = 1.21-1.50; p64+ = 2.18x10-10 , OR64+ = 1.42, 95%CI64+ = 1.27-1.58]) but only in persons >54. There was also a significant association at the previously identifie...Continue Reading

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Citations

Jan 30, 2019·International Journal of Cancer. Journal International Du Cancer·Xiaoming ZhangMian Guo
Jul 14, 2019·Neuro-oncology·Quinn T OstromMelissa L Bondy
Mar 24, 2021·Journal of Neuro-oncology·Quinn T OstromJill S Barnholtz-Sloan
Aug 14, 2021·Aging·Jeanette E Eckel-PassowRobert B Jenkins
Feb 6, 2022·Current Oncology Reports·Carlen A YuenAya Haggiagi
Feb 6, 2022·Journal of Translational Medicine·Wei-Zhi LinChia-Yang Shiau

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