PMID: 3773791Jan 1, 1986Paper

Age-specific prevalence of hepatitis B e antigen (HBeAg) and antibody to HBeAg (anti-HBe) among asymptomatic hepatitis B surface antigen (HBsAg) carriers in Okinawa and Kyushu, Japan

Microbiology and Immunology
S KashiwagiM Kaji

Abstract

A total of 1,741 asymptomatic hepatitis B surface antigen (HBsAg) carriers in two areas (Okinawa and Kyushu) in Japan were surveyed for the presence of hepatitis B e antigen (HBeAg) and the corresponding antibody (anti-HBe) to determine the age-specific prevalence of these markers and the mean age of carriers with HBeAg. Prevalence of HBeAg was significantly higher in Kyushu (36.4% of 755 carriers) than in Okinawa (20.0% of 986 carriers) (P less than 0.001). The mean age of carriers with HBeAg was 25.5 years in Kyushu and 16.1 years in Okinawa, suggesting that HBeAg converted to anti-HBe earlier in Okinawa than in Kyushu. In contrast, the prevalence of anti-HBe was significantly higher in Okinawa (74.6% of 986) than in Kyushu (56.3% of 755) (P less than 0.001). The prevalence of HBeAg decreased with age up to 40-49 years of age and then increased in both areas. Prevalence of anti-HBe was inversely related to the prevalence of HBeAg in both areas. These data suggest that HBeAg and anti-HBe are chronological markers of chronic hepatitis B virus infection and that the duration of HBeAg persistence can be different in different area, even in the same country.

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Citations

Dec 1, 1989·European Journal of Epidemiology·M RapicettaG B Rossi
Apr 1, 1984·The Journal of Hygiene·I EbisawaT Hatashita
Mar 1, 1986·American Journal of Public Health·R Williams
Apr 16, 2004·BMC Family Practice·Suzane Kioko Ono-NitaLuiz Caetano da Silva
Nov 30, 2006·Gastroenterology Clinics of North America·F Blaine Hollinger, Daryl T-Y Lau
Jun 1, 1994·Asia-Oceania Journal of Obstetrics and Gynaecology·H H LinD S Chen
Jan 1, 1991·Annals of Tropical Paediatrics·M RapicettaM Chiaramonte

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