PMID: 8950367Jan 1, 1996Paper

Age-specific prostate-specific antigen: a reassessment

The Prostate. Supplement
R EtzioniM K Brawer

Abstract

Our objective was to compare expected survival benefits when screening for prostate cancer with PSA, using an age-specific bound relative to a cutoff of 4.0 ng/ml. We used a decision analysis modeling the cancer yield in a cohort screened by both screening tests, and the survival of cancer cases given screen detection and in the absence of screening. Expected cancer yields and positive predictive values were from an ultrasound-guided biopsy series. Stage distributions of screen-detected cases were obtained from the literature. For localized causes, survival given screen detection was assumed to be equal to normal life expectancy for the population. For these cases, survival in the absence of screening was modeled as time from clinical diagnosis to death added to time remaining after time of screen and before clinical diagnosis was made (lead time). For nonlocalized cases at screen detection, survival given screen detection was assumed to be equal to survival in the absence of screening. The average difference between expected survival with and without screening as calculated for age-specific PSA and for PSA > 4.0 ng/ml and compared. Average years of life saved per subject screened using PSA > 4.0 ng/ml were comparable to those ...Continue Reading

References

Mar 1, 1992·The Journal of Urology·M K BrawerP H Lange
Apr 25, 1991·The New England Journal of Medicine·W J CatalonaG L Andriole
Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Oct 1, 1989·The Journal of Urology·M A HudsonW J Catalona
Dec 1, 1989·American Journal of Clinical Pathology·M K BrawerJ A Gaines
Jan 29, 1987·The New England Journal of Medicine·S G Pauker, J P Kassirer
Mar 15, 1994·Statistics in Medicine·J D PearsonL J Brant
Nov 1, 1994·The Journal of Urology·J D Pearson, H B Carter
Aug 25, 1993·JAMA : the Journal of the American Medical Association·W J CatalonaJ W Basler

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Citations

Oct 19, 2007·BJU International·Shahrokh F ShariatPierre I Karakiewicz
Nov 14, 2007·Prostate Cancer and Prostatic Diseases·K BensalahS F Shariat
Jan 5, 2000·Seminars in Surgical Oncology·M K Brawer

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