Age-Specific Risk Factors for Advanced Stage Colorectal Cancer, 1981-2013

Preventing Chronic Disease
Kevin J MooreTulay Koru-Sengul

Abstract

Epidemiologic studies have identified an increase in colorectal cancer (CRC) among younger adults. By using a statewide population-based cancer registry, this study examines sociodemographic and clinical disparities in CRC and characterizes advanced stage CRC risk factors with specific attention to age-specific risk factors. Data from the Florida Cancer Data System from 1981 through 2013 were analyzed for adult CRC patients. Patients were divided into 2 age groups: younger than 50 years and 50 years or older. Stage of presentation was categorized as early (localized) or advanced (regional or distant). Multivariable logistic regression models adjusted for sociodemographic and clinical characteristics were fitted to identify risk factors for advanced stage CRC presentation. Adjusted odds ratios were calculated with 95% confidence intervals. From 1981 through 2013, there were 182,095 Florida adults diagnosed with CRC. Those aged younger than 50 years were significantly more likely to have advanced stage CRC compared with those aged 50 or older. Among those younger than 50 years, current and former tobacco smokers and those of black or other race were significantly more likely to have advanced stage CRC. Among those aged 50 or olde...Continue Reading

References

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Citations

Feb 27, 2019·Journal of Surgical Oncology·Rachel M LeeMaria C Russell
Aug 15, 2019·JAMA Network Open·Siran M KoroukianNathan A Berger
Sep 15, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A C ChambersD E Messenger
Jan 23, 2021·Expert Review of Gastroenterology & Hepatology·Obaida DairiLynn F Butterly

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