Age-Stratified Profiles of Serum IL-6, IL-10, and TNF-α Cytokines Among Kenyan Children with Schistosoma haematobium, Plasmodium falciparum, and Other Chronic Parasitic Co-Infections

The American Journal of Tropical Medicine and Hygiene
Amaya L BustinduyCharles H King

Abstract

In a study of children having polyparasitic infections in a Schistosoma haematobium-endemic area, we examined the hypothesis that S. haematobium-positive children, compared with S. haematobium-negative children (anti-soluble worm antigen preparation [SWAP] negative and egg negative) have increased systemic production of pro-inflammatory cytokines (interleukin [IL]-6, tumor necrosis factor [TNF]-α) and decreased down-regulatory IL-10. A total of 804 children, 2-19 years of age, were surveyed between July and December 2009 and tested for S. haematobium, Plasmodium falciparum, filariasis, and soil-transmitted helminth infections. Plasma levels of IL-6, TNF-α, and IL-10 were compared for S. haematobium-positive and S. haematobium-negative children, adjusting for malaria, filaria, and hookworm co-infections, and for nutritional status, age group, sex, and geographic location. IL-10 was significantly elevated among children infected with S. haematobium, showing bimodal peaks in 7-8 and 13-14 years age groups. IL-10 was also higher among children who were acutely malnourished, whereas IL-10 levels were lower in the presence of S. haematobium-filaria co-infection. After adjustment for co-factors, IL-6 was significantly elevated among c...Continue Reading

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Citations

Apr 13, 2017·Malaria Journal·Temitope W AdemolueGordon A Awandare
Jun 16, 2019·Infectious Diseases of Poverty·Shi-Shi ShenZhi-Yue Lv
Aug 2, 2017·Asian Pacific Journal of Tropical Medicine·Wen-Yong XueLei Du
Nov 14, 2017·Tropical Medicine & International Health : TM & IH·Ayodele AdedojaThirumalaisamy P Velavan
Sep 21, 2021·BMC Infectious Diseases·Michael U Anyanwu

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