Abstract
In a study of children having polyparasitic infections in a Schistosoma haematobium-endemic area, we examined the hypothesis that S. haematobium-positive children, compared with S. haematobium-negative children (anti-soluble worm antigen preparation [SWAP] negative and egg negative) have increased systemic production of pro-inflammatory cytokines (interleukin [IL]-6, tumor necrosis factor [TNF]-α) and decreased down-regulatory IL-10. A total of 804 children, 2-19 years of age, were surveyed between July and December 2009 and tested for S. haematobium, Plasmodium falciparum, filariasis, and soil-transmitted helminth infections. Plasma levels of IL-6, TNF-α, and IL-10 were compared for S. haematobium-positive and S. haematobium-negative children, adjusting for malaria, filaria, and hookworm co-infections, and for nutritional status, age group, sex, and geographic location. IL-10 was significantly elevated among children infected with S. haematobium, showing bimodal peaks in 7-8 and 13-14 years age groups. IL-10 was also higher among children who were acutely malnourished, whereas IL-10 levels were lower in the presence of S. haematobium-filaria co-infection. After adjustment for co-factors, IL-6 was significantly elevated among c...Continue Reading
References
May 1, 1985·The American Journal of Tropical Medicine and Hygiene·S E MaddisonR A Pollard
Mar 10, 1999·Parasitology·N B KabatereineA J Fulford
May 6, 1999·The Journal of Infectious Diseases·S M MontenegroT A Wynn
Oct 13, 2001·The Journal of Infectious Diseases·C L KingJ H Ouma
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandrine HenriAlain J Dessein
Jan 11, 2003·Advances in Parasitology·Karl F HoffmannDavid W Dunne
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark BoothDavid W Dunne
Feb 6, 2004·Memórias do Instituto Oswaldo Cruz·Eridan M CoutinhoZilton A Andrade
Feb 1, 2005·Parasite Immunology·T O DialloG Riveau
Jun 22, 2005·Trends in Parasitology·Jennifer F FriedmanStephen T McGarvey
Jul 5, 2005·The Journal of Infectious Diseases·Hannah M CoutinhoJennifer F Friedman
Jan 24, 2006·Infection and Immunity·L F Alves OliveiraR Correa-Oliveira
May 18, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan D KurtisLuz P Acosta
Sep 22, 2006·Infection and Immunity·Kirsten E LykeMarcelo B Sztein
Dec 28, 2006·The Journal of Infectious Diseases·H M CoutinhoJ D Kurtis
Feb 20, 2007·Memórias do Instituto Oswaldo Cruz·Zilton A AndradeThaynã Souto Santana
Jun 5, 2007·Immunobiology·Elly van RietMaria Yazdanbakhsh
Nov 30, 2007·BMC Infectious Diseases·Francisca MutapiRick M Maizels
Jun 28, 2008·The Journal of Infectious Diseases·Violaine ArnaudAlain Dessein
Jun 29, 2010·International Journal for Parasitology·Taniawati SupaliMaria Yazdanbakhsh
Dec 7, 2011·The American Journal of Tropical Medicine and Hygiene·Francis M MutukuUriel Kitron
Jan 18, 2013·The American Journal of Tropical Medicine and Hygiene·Amaya L BustinduyCharles H King
Mar 8, 2013·Trends in Parasitology·J Russell StothardJutta Reinhard-Rupp
Apr 5, 2014·Lancet·Daniel G ColleyCharles H King
Citations
May 28, 2015·The American Journal of Tropical Medicine and Hygiene·Philip MagakCharles H King
Sep 11, 2019·Journal of Helminthology·M M MebiusJ J van Hellemond
Oct 1, 2017·BMC Infectious Diseases·Ye ShenDaniel G Colley
Nov 28, 2017·PLoS Neglected Tropical Diseases·Sarah C Miller-FellowsCharles H King
Apr 13, 2017·Malaria Journal·Temitope W AdemolueGordon A Awandare
Jan 25, 2018·Scandinavian Journal of Immunology·J L Rodrigues OliveiraD Negrão-Corrêa
Jun 16, 2019·Infectious Diseases of Poverty·Shi-Shi ShenZhi-Yue Lv
Aug 2, 2017·Asian Pacific Journal of Tropical Medicine·Wen-Yong XueLei Du
Nov 14, 2017·Tropical Medicine & International Health : TM & IH·Ayodele AdedojaThirumalaisamy P Velavan
Jul 5, 2018·Parasites & Vectors·Aminata Colle LoLinda Eva Amoah
May 20, 2021·African Journal of Laboratory Medicine·Amos MarumeTakafira Mduluza
Sep 21, 2021·BMC Infectious Diseases·Michael U Anyanwu